Gene: BCL7B
Official Full Name: BAF chromatin remodeling complex subunit BCL7Bprovided by HGNC
Gene Summary: This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33378 | BCL7B Knockout cell line (HeLa) | Human | BCL7B | 1:3~1:6 | Negative | Online Inquiry |
KO33379 | BCL7B Knockout cell line (HCT 116) | Human | BCL7B | 1:2~1:4 | Negative | Online Inquiry |
KO33380 | BCL7B Knockout cell line (HEK293) | Human | BCL7B | 1:3~1:6 | Negative | Online Inquiry |
KO33381 | BCL7B Knockout cell line (A549) | Human | BCL7B | 1:3~1:4 | Negative | Online Inquiry |
BCL7B Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted genetic modification to eliminate the expression of the BCL7B gene. This gene plays a significant role in various cellular processes, including apoptosis and cell cycle regulation. The knockout of BCL7B facilitates the study of its functions in cellular differentiation and oncogenesis, making these cell lines invaluable tools for researchers focused on cancer biology and therapeutic development.
The primary function of these cell lines is to provide a controlled environment for examining the biological consequences of BCL7B deficiency. By employing CRISPR-Cas9 or other gene-editing technologies, the BCL7B Gene Knockout Cell Lines allow for precise modifications, enabling researchers to dissect the gene's role in signaling pathways associated with tumorigenesis and cell proliferation. This mechanistic insight is critical for understanding the molecular underpinnings of various cancers, facilitating the identification of potential clinical targets.
In clinical and research settings, BCL7B knockout models are particularly valuable for drug development and testing novel therapeutic strategies. By enabling scientists to explore the effects of different compounds on BCL7B-deficient cells, these models aid in determining the efficacy and safety of potential treatments. Furthermore, they contribute to the validation of biomarkers and the development of personalized medicine approaches.
Compared to other gene knockout models, BCL7B Gene Knockout Cell Lines stand out for their specificity and reliability. They provide a robust and reproducible platform that minimizes off-target effects, thus ensuring that observed phenotypes are directly attributable to the loss of BCL7B function. This precision enhances the credibility of experimental results and accelerates the pathway from laboratory discovery to clinical application.
Researchers and clinicians will find immense value in utilizing BCL7B Gene Knockout Cell Lines to advance their investigations into cancer biology, potentially leading to breakthroughs in treatment methodologies. Our company, with a dedication to providing high-quality biological products, offers these cutting-edge tools backed by rigorous validation and expert support, ensuring researchers can confidently rely on our offerings for their critical work in understanding complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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