Gene: BCAR3
Official Full Name: BCAR3 adaptor protein, NSP family memberprovided by HGNC
Gene Summary: Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01789 | BCAR3 Knockout cell line (HeLa) | Human | BCAR3 | 1:3~1:6 | Negative | Online Inquiry |
KO01790 | BCAR3 Knockout cell line (HCT 116) | Human | BCAR3 | 1:2~1:4 | Negative | Online Inquiry |
KO01791 | BCAR3 Knockout cell line (HEK293) | Human | BCAR3 | 1:3~1:6 | Negative | Online Inquiry |
KO01792 | BCAR3 Knockout cell line (A549) | Human | BCAR3 | 1:3~1:4 | Negative | Online Inquiry |
BCAR3 Gene Knockout Cell Lines are innovative biological research tools designed to facilitate the study of cancer biology, specifically focusing on cell signaling pathways and therapeutic responses. These cell lines have been genetically modified to disrupt the BCAR3 gene, known for its role in mediating estrogen receptor signaling and cellular responses to growth factors. By knocking out this gene, researchers can accurately assess the functional impacts of BCAR3 deficiency on tumorigenesis, metastasis, and cell proliferation.
The primary mechanism of action involves the manipulation of intracellular signaling networks that govern cell fate decisions in response to hormonal stimuli and environmental stressors. This disruption can lead to altered cell behavior, providing insights into the oncogenic processes that drive cancer progression and treatment resistance. Additionally, the BCAR3 Gene Knockout Cell Lines are invaluable for testing the efficacy of novel therapeutics, as these models can reveal how cells adapt to targeted therapies and help identify potential biomarkers for patient stratification.
From a scientific perspective, the BCAR3 Gene Knockout Cell Lines are crucial not only for basic research but also for translational applications within oncology. Researchers can leverage these tools to explore the mechanistic roles of the BCAR3 gene in various cancer types, facilitating a deeper understanding of disease pathways and therapeutic vulnerabilities.
What sets these cell lines apart from conventional models is their specificity and precision, allowing for reproducible experimental outcomes that can enhance the reliability of research findings. Economically, researchers and clinicians can save time and resources by using these ready-to-use knockout models, which eliminate the need for lengthy genetic manipulation processes.
In summary, the BCAR3 Gene Knockout Cell Lines represent a significant advancement in genetic research tools, equipping scientists and clinicians with the capabilities to deepen their understanding of cancer biology. Our company, with its commitment to delivering high-quality biological products supported by extensive scientific expertise, stands at the forefront of enabling groundbreaking discoveries in cancer research and therapy.
Please note that all services are for research use only. Not intended for any clinical use.
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