Gene: BAMBI
Official Full Name: BMP and activin membrane bound inhibitorprovided by HGNC
Gene Summary: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11591 | BAMBI Knockout cell line (HeLa) | Human | BAMBI | 1:3~1:6 | Negative | Online Inquiry |
KO11592 | BAMBI Knockout cell line (HCT 116) | Human | BAMBI | 1:2~1:4 | Negative | Online Inquiry |
KO11593 | BAMBI Knockout cell line (HEK293) | Human | BAMBI | 1:3~1:6 | Negative | Online Inquiry |
KO11594 | BAMBI Knockout cell line (A549) | Human | BAMBI | 1:3~1:4 | Negative | Online Inquiry |
BAMBI Gene Knockout Cell Lines are advanced tools designed for researchers engaged in the study of cellular signaling pathways, gene function, and potential therapeutic interventions. These cell lines are engineered to have the BAMBI gene (Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor) completely knocked out, facilitating insights into its role in regulating TGF-beta superfamily signaling, cellular differentiation, and immune responses.
The key functionality of BAMBI Gene Knockout Cell Lines lies in their ability to provide a clear genetic background in which the downstream effects of BAMBI absence can be studied. This allows researchers to elucidate the mechanistic pathways influenced by this gene, offering a powerful platform for investigating the roles of genetic variations in various diseases, including cancer and fibrotic disorders. The knockout of the BAMBI gene leads to altered signaling cascades, making these cell lines invaluable for studying the intricacies of cell behavior and response to environmental stimuli.
Scientifically, the significance of these cell lines extends into both basic and applied research. In clinical settings, they can serve as models for drug testing and biomarker discovery, contributing to personalized medicine approaches. Their ability to simulate human disease conditions enhances the translational potential of findings, facilitating progress towards therapeutic strategies.
Compared to alternative options, BAMBI Gene Knockout Cell Lines offer unique advantages including consistent expression profiles, genetic stability, and a robust platform for targeted gene editing and analysis. This specificity enhances reproducibility in experiments, allowing researchers to derive meaningful conclusions with higher confidence. Furthermore, the ease of use in downstream applications, including CRISPR/Cas9 genome editing, makes these cell lines particularly appealing.
For researchers and clinicians focused on advancing knowledge in genetic regulation and cell signaling, BAMBI Gene Knockout Cell Lines represent a crucial resource that empowers deeper exploration and innovation. Our company is committed to providing top-tier biological products backed by extensive expertise in molecular biology and cellular engineering, ensuring reliability and excellence in every product offering.
Please note that all services are for research use only. Not intended for any clinical use.
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