Gene: B3GNT3
Official Full Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3provided by HGNC
Gene Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06684 | B3GNT3 Knockout cell line (HCT 116) | Human | B3GNT3 | 1:2~1:4 | Negative | Online Inquiry |
KO06685 | B3GNT3 Knockout cell line (A549) | Human | B3GNT3 | 1:3~1:4 | Negative | Online Inquiry |
B3GNT3 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to eliminate the B3GNT3 gene, which encodes an enzyme responsible for the synthesis of specific glycosylation patterns on proteins. These cell lines serve as a crucial tool for researchers interested in understanding the role of glycosylation in cellular processes, disease pathogenesis, and the development of therapeutic strategies.
The key function of the B3GNT3 knockout cell lines is to facilitate the study of glycan structures that impact cell signaling, immunity, and carbohydrate recognition. By creating a model devoid of the B3GNT3 gene, researchers can elucidate the functional consequences of altered glycosylation patterns and investigate its implications in diseases such as cancer, autoimmune disorders, and infectious diseases. The mechanisms at play in these knockout lines allow scientists to assess changes in cell behavior, molecular interactions, and signal transduction pathways in a controlled environment.
The scientific importance of B3GNT3 Gene Knockout Cell Lines cannot be overstated, as they provide insights into fundamental biological processes and have significant applications in both research and clinical settings. They can aid in the development of novel therapeutic approaches targeting glycosylation pathways, thus broadening the horizon for drug discovery and personalized medicine. Furthermore, these cell lines can be utilized in high-throughput screening, enabling the identification of compounds that can modulate glycosylation in target cells.
In comparison to traditional cell lines, B3GNT3 knockout models offer a unique advantage by providing specific genetic modifications that address the limitations of non-targeted approaches. Researchers can achieve more precise results while reducing variability, allowing for reproducible and impactful findings. The availability of well-characterized knockout lines also enhances the credibility of studies aimed at unraveling the complexities of glycobiology.
For researchers, clinicians, and biotechnology companies, investing in B3GNT3 Gene Knockout Cell Lines can unlock avenues for novel discoveries and innovation in therapeutic development. By providing a reliable and effective model for understanding glycan-mediated interactions, these cell lines can contribute significantly to advancing scientific knowledge and clinical practices.
As a leading provider of genetic engineering solutions, we at [Company Name] pride ourselves on delivering high-quality cellular products that empower the scientific community. Our expertise in cell line development ensures that you receive robust models that meet the needs of your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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