Gene: AR
Official Full Name: androgen receptorprovided by HGNC
Gene Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00170 | Ar gRNA1-gRNA2 KO plasmid | Ar | $850 | |||
KO01122 | Ar Knockout cell line(4T1) | Mouse | Ar | 1:3~1:4 | Negative | Online Inquiry |
AR Gene Knockout Cell Lines are highly specialized biological tools designed to facilitate the study of gene functions, particularly those related to the androgen receptor (AR) signaling pathways. These cell lines have been engineered using advanced CRISPR/Cas9 technology, resulting in complete knockout of the AR gene. This modification allows researchers to investigate the physiological and pathological roles of AR in various cellular contexts, including cancer biology, endocrine signaling, and reproductive health.
The primary function of AR Gene Knockout Cell Lines lies in their ability to mimic the loss-of-function mutations found in certain diseases, thereby enabling the examination of AR’s impact on tumor growth, differentiation, and response to hormonal therapies. By utilizing these knockout models, scientists can dissect complex signaling networks, study compensatory mechanisms, and identify potential therapeutic targets with greater precision.
In both research and clinical settings, AR Gene Knockout Cell Lines are invaluable as they provide robust models for drug screening, biomarker discovery, and understanding resistance mechanisms in hormone-dependent cancers. Compared to other models, such as using siRNA or shRNA approaches, these knockout cell lines offer a more permanent and comprehensive alteration of gene expression, resulting in more reliable and reproducible data.
The unique selling points of AR Gene Knockout Cell Lines include their validated efficacy, high specificity, and ease of use, which allow for straightforward integration into existing workflows. Researchers can confidently employ these cell lines to drive innovation in therapeutic developments, enhancing the understanding of AR-targeted interventions in clinical practice.
Our company boasts a strong track record in developing cutting-edge biological products that empower researchers, and we maintain a commitment to quality and scientific excellence. With AR Gene Knockout Cell Lines as part of our offerings, we provide essential tools that accelerate scientific discovery and promote advancements in personalized medicine.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.