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Alkbh1 Knockout Cell Lines

Gene: Alkbh1

Official Full Name: alkB homolog 1, histone H2A dioxygenaseprovided by MGI

Gene Summary: Enables broad specificity oxidative DNA demethylase activity and chemoattractant activity. Involved in positive regulation of gene expression, epigenetic and regulation of translational initiation by tRNA modification. Acts upstream of or within several processes, including generation of neurons; in utero embryonic development; and negative regulation of neuron apoptotic process. Located in euchromatin. Is expressed in several structures, including branchial arch; central nervous system; hemolymphoid system gland; hindlimb muscle; and limb bud. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01119 Alkbh1 Knockout cell line(MC38) Mouse Alkbh1 1:2-1:4 Negative Online Inquiry

Background

Alkbh1 Gene Knockout Cell Lines are specialized cellular models in which the Alkbh1 gene has been systematically disrupted or "knocked out," resulting in a unique tool for studying the biological implications of Alkbh1 in various cellular processes. This gene encodes for the alkylation repair enzyme ALKBH1, which is involved in the demethylation of RNA and plays a crucial role in the regulation of gene expression and cellular response to stressors.

By utilizing the Alkbh1 gene knockout cell lines, researchers can investigate the specific mechanisms through which ALKBH1 influences RNA metabolism and potential pathways leading to altered cell function. This allows for deeper insights into critical mechanisms of gene regulation, as well as the cellular responses to environmental stimuli. The absence of ALKBH1 in these cell lines can reveal the consequences of disrupted methylation processes, providing a valuable context for understanding the role of RNA modifications in health and disease.

The scientific importance of Alkbh1 gene knockout cell lines extends into several research domains, including cancer biology, neurobiology, and studies concerning metabolic disorders. These models facilitate advanced investigations into the molecular underpinnings of various pathologies, enhancing the development of targeted therapeutic strategies.

A key advantage of using Alkbh1 gene knockout cell lines compared to traditional methods, such as pharmacological inhibition or transient gene silencing, is the permanent and stable alteration of the Alkbh1 gene; this allows for long-term studies without the variability introduced by transient manipulations. Additionally, these models provide a more physiologically relevant context to observe the cellular effects over extended periods.

For researchers and clinicians, the value of this product lies in its ability to elucidate the complex roles of ALKBH1, paving the way for novel insights into the regulatory networks influencing cell viability and disease progression. Utilizing these cell lines helps bridge gaps in knowledge and fosters innovation in therapeutic development.

As a company committed to advancing scientific research, we specialize in providing high-quality genetic models that empower researchers. Our expertise ensures that our Alkbh1 gene knockout cell lines meet rigorous standards, supporting impactful discoveries in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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