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ATXN7L3 Knockout Cell Lines

Gene: ATXN7L3

Official Full Name: ataxin 7 like 3provided by HGNC

Gene Summary: Enables nuclear receptor coactivator activity. Involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleus. Part of DUBm complex and SAGA complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19541 ATXN7L3 Knockout cell line (HeLa) Human ATXN7L3 1:3~1:6 Negative Online Inquiry
KO19542 ATXN7L3 Knockout cell line (HCT 116) Human ATXN7L3 1:2~1:4 Negative Online Inquiry
KO19543 ATXN7L3 Knockout cell line (HEK293) Human ATXN7L3 1:3~1:6 Negative Online Inquiry
KO19544 ATXN7L3 Knockout cell line (A549) Human ATXN7L3 1:3~1:4 Negative Online Inquiry

Background

ATXN7L3 Gene Knockout Cell Lines are engineered cellular models designed to specifically disable the expression of the ATXN7L3 gene. This innovative product allows researchers to study the functional implications of ATXN7L3 loss-of-function and its role in various cellular processes, particularly in the context of neurodegenerative diseases and other disorders associated with protein aggregation.

The key function of these knockout cell lines involves a targeted disruption of the ATXN7L3 gene via advanced CRISPR-Cas9 technology, leading to the elimination of the gene's expression. This results in a unique cellular environment that mimics pathological states, enabling scientists to investigate the downstream effects of ATXN7L3 deficiency, including alterations in protein homeostasis, RNA processing, and cellular stress responses. The product thus serves as a potent tool for delineating the biological pathways impacted by the absence of this gene.

The scientific importance of ATXN7L3 Gene Knockout Cell Lines cannot be overstated, as they provide critical insights into the mechanisms underlying disorders such as spinocerebellar ataxia and other neurodegenerative conditions. In both research and clinical settings, these cell lines can facilitate the development of therapeutic strategies aimed at ameliorating symptoms or preventing disease progression by allowing for the screening of pharmacological agents or gene therapies.

Compared to alternative systems, such as transient knockdown models, our knockout cell lines provide a stable and reproducible platform, delivering consistent results across experiments. This reliability is crucial for producing high-quality data and accelerating the research process, ultimately enhancing the potential for successful outcomes in translational studies.

By integrating ATXN7L3 Gene Knockout Cell Lines into their research workflows, scientists and clinicians are empowered with the means to advance our understanding of complex biological processes, paving the way for innovative therapeutic interventions. Our company prides itself on its dedication to precision and quality in biological product development, backed by a team of experts committed to supporting cutting-edge research in biosciences.

Please note that all services are for research use only. Not intended for any clinical use.

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