Gene: ATF3
Official Full Name: activating transcription factor 3provided by HGNC
Gene Summary: This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00477 | ATF3 Knockout cell line (A549) | Human | ATF3 | 1:3~1:4 | Negative | Online Inquiry |
KO01773 | ATF3 Knockout cell line (HeLa) | Human | ATF3 | 1:3~1:6 | Negative | Online Inquiry |
KO01774 | ATF3 Knockout cell line (HCT 116) | Human | ATF3 | 1:2~1:4 | Negative | Online Inquiry |
KO01775 | ATF3 Knockout cell line (HEK293) | Human | ATF3 | 1:3~1:6 | Negative | Online Inquiry |
ATF3 Gene Knockout Cell Lines are specially engineered cellular models featuring targeted disruption of the activating transcription factor 3 (ATF3) gene. This gene plays a critical role in cellular responses to stress and is implicated in various physiological and pathological processes, including inflammation, apoptosis, and oncogenesis. By creating knockout cell lines, researchers gain invaluable tools for dissecting the functional roles of ATF3 in cellular pathways and identifying its involvement in disease states, particularly cancer and metabolic disorders.
The key mechanism of these cell lines lies in their inability to express ATF3, allowing for the observation of cellular behaviors in conditions where this transcription factor is typically active. This unique attribute facilitates the study of gene regulation, signaling pathways, and the impact of ATF3 on various stress-response mechanisms. Utilizing these knockout models, researchers can explore the molecular underpinnings of diseases in environments mimicking physiological or pathological conditions, providing insights that are vital for developing potential therapeutic strategies.
The scientific importance of ATF3 Gene Knockout Cell Lines extends into both research and clinical laboratories. These cell lines are essential for advancing our understanding of gene function and pathology, enhancing drug discovery processes, and optimizing therapeutic interventions targeting stress responses or tumorigenesis. Furthermore, they offer a significant advantage over alternative models by providing a precise understanding of the gene's influence without the confounding effects of ATF3 activity.
Researchers and clinicians can leverage these knockout cell lines to generate reproducible and relevant data that can facilitate precision medicine approaches and enable the development of more effective treatments. The valuable data obtained can lead to breakthroughs in therapeutic targeting and improve predictive models of disease progression.
At [Your Company Name], our expertise in cell line development and molecular biology ensures the highest quality products that meet the exacting needs of scientific inquiry. We are committed to providing researchers with innovative tools like ATF3 Gene Knockout Cell Lines that drive advancements in understanding complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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