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ATE1 Knockout Cell Lines

Gene: ATE1

Official Full Name: arginyltransferase 1provided by HGNC

Gene Summary: This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31198 ATE1 Knockout cell line (HeLa) Human ATE1 1:3~1:6 Negative Online Inquiry
KO31199 ATE1 Knockout cell line (HCT 116) Human ATE1 1:2~1:4 Negative Online Inquiry
KO31200 ATE1 Knockout cell line (HEK293) Human ATE1 1:3~1:6 Negative Online Inquiry
KO31201 ATE1 Knockout cell line (A549) Human ATE1 1:3~1:4 Negative Online Inquiry

Background

ATE1 Gene Knockout Cell Lines are specially engineered cell lines that have undergone precise modification to disrupt the expression of the ATE1 gene, which encodes the enzyme aminoacyl-tRNA editing. This product utilises advanced CRISPR-Cas9 technology to create a loss-of-function knockout of the gene, enabling researchers to study the impact of ATE1 deficiency on cellular processes such as protein synthesis, stress responses, and overall cellular metabolism.

The key function of ATE1 gene knockout cell lines lies in their ability to facilitate the detailed study of the physiological roles of the ATE1 gene and its associated pathways. By analyzing these knockout variants, researchers can delve into the implications of ATE1 in various biological contexts, including its contribution to disease mechanisms, cellular stress responses, and the regulation of translational fidelity. Understanding these pathways is crucial in both basic research and therapeutic development, particularly in the context of diseases where protein misfolding plays a pivotal role.

In terms of scientific importance, ATE1 Gene Knockout Cell Lines serve a vital role in biomedical research and drug discovery. Their utility extends to pharmacological studies, enabling the identification of novel compounds that might correct or compensate for the dysfunction caused by the loss of ATE1 activity. This product also stands out for its specificity and reliability; alternate models often do not replicate the complex effects of gene knockout as effectively, making ATE1 knockout cell lines a more robust choice for rigorous scientific investigations.

Researchers and clinicians will find significant value in utilizing these cell lines due to their precise genetic modifications, which ultimately enhance experimental accuracy and reproducibility. Additionally, the availability of well-characterized knockout models simplifies the interpretation of results and supports hypothesis-driven research.

At [Your Company Name], we are dedicated to advancing scientific discovery through the provision of high-quality biological products. Our expertise in genetic engineering ensures that ATE1 Gene Knockout Cell Lines are developed with meticulous attention to detail, providing researchers with the tools they need to drive innovation and breakthroughs in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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