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ATAD3A Knockout Cell Lines

Gene: ATAD3A

Official Full Name: ATPase family AAA domain containing 3Aprovided by HGNC

Gene Summary: This gene encodes a ubiquitously expressed mitochondrial membrane protein that contributes to mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. This gene is a member of the ATPase family AAA-domain containing 3 gene family which, in humans, includes two other paralogs. Naturally occurring mutations in this gene are associated with distinct neurological syndromes including Harel-Yoon syndrome. High-level expression of this gene is associated with poor survival in breast cancer patients. A homozygous knockout of the orthologous gene in mice results in embryonic lethality at day 7.5 due to growth retardation and defective development of the trophoblast lineage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19619 ATAD3A Knockout cell line (HeLa) Human ATAD3A 1:3~1:6 Negative Online Inquiry
KO19620 ATAD3A Knockout cell line (HCT 116) Human ATAD3A 1:2~1:4 Negative Online Inquiry
KO19621 ATAD3A Knockout cell line (HEK293) Human ATAD3A 1:3~1:6 Negative Online Inquiry
KO19622 ATAD3A Knockout cell line (A549) Human ATAD3A 1:3~1:4 Negative Online Inquiry

Background

ATAD3A Gene Knockout Cell Lines are specialized, genetically modified cell lines designed to silence the expression of the ATAD3A gene, which encodes for a critical ATPase involved in mitochondrial function and cellular metabolism. By utilizing CRISPR/Cas9 technology, these cell lines offer researchers an invaluable tool for studying the role of ATAD3A in disease processes, mitochondrial dynamics, and genetic regulation. The knockout mechanism effectively disrupts the transcription of the gene, allowing for the investigation of phenotypic changes that occur in the absence of this protein.

The key function of ATAD3A is its involvement in mitochondrial biogenesis, lipid metabolism, and the maintenance of mitochondrial DNA. This gene has been implicated in various pathologies, including neurodegenerative diseases and certain types of cancer. By using ATAD3A Gene Knockout Cell Lines, researchers can explore the intricate interactions of mitochondrial functions with cellular pathways, thus enhancing our understanding of mitochondrial-related diseases. In clinical settings, these cell lines can be instrumental in drug discovery, as they provide a platform for testing the efficacy of therapeutic agents targeting mitochondrial dysfunction.

One of the primary advantages of using ATAD3A Gene Knockout Cell Lines is the specificity and precision of gene editing achieved through CRISPR technology, which surpasses traditional methods such as RNA interference in terms of off-target effects and ease of manipulation. Additionally, these cell lines can be easily adapted for high-throughput screening, aligning with the fast-paced demands of modern biomedical research.

For researchers and clinicians, the value of ATAD3A Gene Knockout Cell Lines lies in their ability to facilitate in-depth investigations into mitochondrial pathology and therapeutic interventions. They provide a reliable model for studying the underlying mechanisms of diseases, thereby expediting the development of novel treatments.

Our company specializes in advanced genetic engineering and offers a comprehensive suite of products tailored to meet the diverse needs of the scientific community. With a strong commitment to quality and innovation, we ensure that our ATAD3A Gene Knockout Cell Lines are rigorously validated for consistent performance, helping researchers unlock new insights in the field of cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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