Gene: ATAD2
Official Full Name: ATPase family AAA domain containing 2provided by HGNC
Gene Summary: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27218 | ATAD2 Knockout cell line (HeLa) | Human | ATAD2 | 1:3~1:6 | Negative | Online Inquiry |
KO27219 | ATAD2 Knockout cell line (HCT 116) | Human | ATAD2 | 1:2~1:4 | Negative | Online Inquiry |
KO27220 | ATAD2 Knockout cell line (HEK293) | Human | ATAD2 | 1:3~1:6 | Negative | Online Inquiry |
KO27221 | ATAD2 Knockout cell line (A549) | Human | ATAD2 | 1:3~1:4 | Negative | Online Inquiry |
ATAD2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the ATAD2 gene, which encodes for a protein involved in chromatin remodeling and gene transcription regulation. These knockout models allow researchers to investigate the functional role of ATAD2 in various biological processes, such as cell proliferation, differentiation, and apoptosis, paving the way for a deeper understanding of its implications in cancer and other diseases.
The key mechanism of action of ATAD2 involves its role as a reader of epigenetic marks and an integral component in the transcriptional machinery. By knocking out this gene, researchers can elucidate its contribution to chromatin structure and gene expression modulation, providing critical insights into gene regulatory networks. This can facilitate studies related to the development of targeted therapies, particularly in oncology, where ATAD2 has been implicated in tumor progression and metastasis.
The scientific importance of ATAD2 Gene Knockout Cell Lines is underscored by their versatility in research and clinical applications. They serve as invaluable tools for drug discovery, allowing for the identification of novel therapeutic targets and the evaluation of drug efficacy in a controlled setting. Additionally, these models can be utilized to better understand drug resistance mechanisms in cancer treatments.
Compared to alternative models, such as transient knockdown or wild-type cell lines, ATAD2 Gene Knockout Cell Lines provide a more stable and permanent genetic modification, ensuring consistent, reproducible results and facilitating long-term studies. This enhances the reliability of experimental outcomes, ultimately streamlining the research process.
For researchers and clinicians focusing on gene function and therapeutic development, these knockout cell lines represent a vital leap forward. They encapsulate the cutting-edge intersection of molecular biology and therapeutic innovation, granting users access to deeper insights into gene regulation mechanisms and potential therapeutic avenues.
Our company specializes in high-quality genetic model development, leveraging advanced techniques and a commitment to innovation, ensuring that our users have access to robust research tools that drive scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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