Gene: ARHGEF28
Official Full Name: Rho guanine nucleotide exchange factor 28provided by HGNC
Gene Summary: This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19703 | ARHGEF28 Knockout cell line (HeLa) | Human | ARHGEF28 | 1:3~1:6 | Negative | Online Inquiry |
KO19704 | ARHGEF28 Knockout cell line (HCT 116) | Human | ARHGEF28 | 1:2~1:4 | Negative | Online Inquiry |
KO19705 | ARHGEF28 Knockout cell line (HEK293) | Human | ARHGEF28 | 1:3~1:6 | Negative | Online Inquiry |
KO19706 | ARHGEF28 Knockout cell line (A549) | Human | ARHGEF28 | 1:3~1:4 | Negative | Online Inquiry |
ARHGEF28 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular and cellular biology, designed specifically to facilitate the study of the Rho guanine nucleotide exchange factor 28 (ARHGEF28) gene. These engineered cell lines enable researchers to effectively investigate the functional implications of the ARHGEF28 gene by providing a controlled environment where this gene is completely inactivated. The knockout mechanism employs CRISPR-Cas9 technology, ensuring precise targeting and disruption of the gene of interest, which allows for subsequent analysis of cellular pathways and physiological responses in the absence of ARHGEF28 expression.
The primary function of these cell lines revolves around their ability to elucidate the role of ARHGEF28 in cell signaling pathways, particularly those involved in cytoskeletal organization, cellular migration, and tumorigenesis. By utilizing ARHGEF28 knockout models, researchers can conduct in-depth studies on the gene’s contribution to oncogenic processes, investigate the effects of gene suppression on specific cellular behaviors, and develop targeted therapies aimed at related pathologies.
The scientific importance of ARHGEF28 Gene Knockout Cell Lines lies in their breadth of applications in both basic research and clinical contexts. They serve as indispensable models for understanding complex diseases, including cancer and neurological disorders, which may be influenced by aberrant ARHGEF28 signaling. Moreover, the insights gained from these studies can lead to the identification of novel therapeutic targets, promoting advancements in personalized medicine.
What sets our ARHGEF28 Gene Knockout Cell Lines apart from alternatives on the market is their rigorous validation and quality assurance process, which guarantees consistency and reliability in experimental outcomes. Researchers benefit from their user-friendly protocols, optimized for various assays, including gene expression analysis, drug screening, and the investigation of phenotypic changes.
For researchers, clinicians, and biotech developers looking to expand their understanding of cellular dynamics related to ARHGEF28, these knockout cell lines present a uniquely valuable resource. With our commitment to excellence in biological research tools and our extensive experience in genetic modification technologies, we ensure that our products facilitate groundbreaking discoveries and advancements in the life sciences sector.
Please note that all services are for research use only. Not intended for any clinical use.
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