Gene: ARHGDIG
Official Full Name: Rho GDP dissociation inhibitor gammaprovided by HGNC
Gene Summary: The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38928 | ARHGDIG Knockout cell line (HEK293) | Human | ARHGDIG | 1:3~1:6 | Negative | Online Inquiry |
KO38929 | ARHGDIG Knockout cell line (A549) | Human | ARHGDIG | 1:3~1:4 | Negative | Online Inquiry |
ARHGDIG Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to lack the expression of the Rho GTPase-activating protein 6 (ARHGDIG) gene. This product serves as a crucial tool for researchers studying various biological processes, particularly those related to cellular signaling, proliferation, and migration. By providing a controlled environment where the effects of the absence of ARHGDIG can be systematically assessed, these knockout cell lines enable detailed investigations into the gene's role in cellular function and disease mechanisms.
The key function of the ARHGDIG knockout cell lines lies in their ability to facilitate the study of Rho family GTPases, essential regulators of cytoskeletal dynamics and cellular behavior. Upon knockout of the ARHGDIG gene, downstream signaling pathways and their implications on cellular activities such as adhesion, motility, and cell cycle regulation can be thoroughly examined. This manifests in vital research applications ranging from cancer biology to neurobiology, as altered Rho GTPase signaling is implicated in various pathologies.
In comparison to alternative models, such as knockdown techniques or wild-type cell lines, these knockout cell lines offer a more definitive means of demonstrating the functional consequences of gene disruption. Researchers can thus obtain clearer insights into gene function without the ambiguity introduced by residual gene activity or compensatory pathways. This specificity is particularly advantageous for both basic research and drug development, where precise targeting and understanding of molecular pathways are paramount.
The value of ARHGDIG Gene Knockout Cell Lines extends to both researchers and clinicians, as they provide critical insights into the mechanisms of disease and potential therapeutic targets. By utilizing these advanced cell lines, users stand to enhance their research outcomes, contributing to significant advancements in both science and medicine.
With extensive expertise in genetic engineering and cell biology, our company specializes in delivering high-quality biological products that empower scientific innovation and discovery. Our commitment to excellence ensures that you have the reliability and support needed to propel your research forward.
Please note that all services are for research use only. Not intended for any clinical use.
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