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ARHGAP19 Knockout Cell Lines

Gene: ARHGAP19

Official Full Name: Rho GTPase activating protein 19provided by HGNC

Gene Summary: Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24372 ARHGAP19 Knockout cell line (HeLa) Human ARHGAP19 1:3~1:6 Negative Online Inquiry
KO24373 ARHGAP19 Knockout cell line (HCT 116) Human ARHGAP19 1:2~1:4 Negative Online Inquiry
KO24374 ARHGAP19 Knockout cell line (HEK293) Human ARHGAP19 1:3~1:6 Negative Online Inquiry
KO24375 ARHGAP19 Knockout cell line (A549) Human ARHGAP19 1:3~1:4 Negative Online Inquiry

Background

ARHGAP19 Gene Knockout Cell Lines represent a cutting-edge biological tool designed for the in-depth study of the Rho GTPase activation regulation pathways and their implications in various cellular processes, including cytoskeletal organization and cell migration. By providing a model that lacks the ARHGAP19 gene, these cell lines facilitate the examination of the specific roles and mechanisms through which ARHGAP19 influences cellular behavior and signaling cascades.

The key functionality of ARHGAP19 is to regulate Rho family GTPases, which are crucial mediators of actin dynamics and cellular morphology. The knockout of ARHGAP19 allows researchers to observe downstream effects on RhoA, Rac1, and Cdc42 signaling pathways. This enables a clearer understanding of how disturbances in these pathways can contribute to pathological conditions such as cancer metastasis and developmental disorders.

From a scientific perspective, these knockout cell lines are invaluable for both research and clinical applications. They can be utilized in studies exploring the fundamental mechanisms of various diseases, including their potential to identify new therapeutic targets. Furthermore, they are essential for validating the effects of pharmacological interventions aimed at modulating Rho GTPase activity.

In comparison to alternative knockout models, the ARHGAP19 Gene Knockout Cell Lines offer superior specificity and reliability, created using advanced CRISPR/Cas9 technology, ensuring accurate gene deletion with minimal off-target effects. This precision enhances reproducibility in research findings, making it a highly advantageous option for investigators focused on cellular signaling and its implications in health and disease.

For researchers and clinicians alike, ARHGAP19 Gene Knockout Cell Lines provide an unprecedented opportunity to gain insights into complex biological pathways. By leveraging these cell models, users can accelerate discovery and innovation within the field of cellular biology. Our company excels in delivering high-quality, cutting-edge research tools specifically designed to meet the evolving needs of the scientific community, reaffirming our commitment to advancing bioscience research through innovation and expertise.

Please note that all services are for research use only. Not intended for any clinical use.

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