Gene: ARF4
Official Full Name: ARF GTPase 4provided by HGNC
Gene Summary: This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38955 | ARF4 Knockout cell line (HeLa) | Human | ARF4 | 1:3~1:6 | Negative | Online Inquiry |
KO38956 | ARF4 Knockout cell line (HCT 116) | Human | ARF4 | 1:2~1:4 | Negative | Online Inquiry |
KO38957 | ARF4 Knockout cell line (HEK293) | Human | ARF4 | 1:3~1:6 | Negative | Online Inquiry |
ARF4 Gene Knockout Cell Lines are specialized biological reagents designed to facilitate comprehensive studies into the function of the ARF4 gene, a regulator known to play a pivotal role in vesicle trafficking and cytoskeletal organization. These cell lines, created through advanced CRISPR/Cas9 genome-editing technology, enable researchers to systematically investigate the phenotypic and molecular consequences of ARF4 ablation, thus providing insights into its contributions to cellular processes.
The key functionality of the ARF4 Gene Knockout Cell Lines lies in their ability to mimic loss-of-function scenarios in vitro. By knocking out the ARF4 gene, these cell lines allow researchers to explore changes in cellular morphology, protein localization, and signaling pathways that are typically influenced by ARF4 activity. This mechanistic understanding is vital, as ARF4 has implications in various biological contexts, including cancer progression and neurodegenerative diseases, making these cell lines indispensable tools in both basic and applied research.
Scientifically, the ARF4 Gene Knockout Cell Lines fill a critical niche in translational research and drug development. Their use extends to functional assays that inform on potential therapeutic targets, biochemical pathways, and disease mechanisms. Unlike traditional knockdown methods such as siRNA, the knockout approach offers a permanent gene alteration, providing more consistent and reliable experimental outcomes. This enhanced stability significantly reduces variability in results, allowing for clearer interpretations of data.
The unique selling points of our ARF4 Gene Knockout Cell Lines include their high efficiency and reproducibility, which are hallmarks of our optimization processes that ensure rigorous quality control. Furthermore, these cell lines are supported by extensive documentation, including characterization data that validates their use and facilitates easier integration into ongoing research projects.
Ultimately, the value of ARF4 Gene Knockout Cell Lines lies in their ability to empower researchers and clinicians to decipher the complexities of ARF4-related mechanisms, thus accelerating the discovery of novel therapies and diagnostic tools. Our company, specializing in advanced gene-editing solutions, stands at the forefront of biotechnology, offering products backed by expert analysis and a commitment to enhancing scientific innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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