Gene: APOH
Official Full Name: apolipoprotein Hprovided by HGNC
Gene Summary: Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05969 | APOH Knockout cell line (A549) | Human | APOH | 1:3~1:4 | Negative | Online Inquiry |
APOH Gene Knockout Cell Lines are sophisticated genetically modified cell systems designed specifically for the study of the Apolipoprotein H (APOH) gene and its associated pathways. These models facilitate a precise understanding of APOH function and its implications in various physiological and pathological contexts, particularly concerning lipid metabolism, immune response, and cardiovascular diseases. By knocking out the APOH gene, researchers can effectively dissect the role of this gene and its protein product in influencing cellular processes and interactions.
The key function of APOH Gene Knockout Cell Lines is the elimination of the gene's expression, allowing scientists to observe the biological effects and phenotypic changes resulting from the absence of APOH. This is achieved through advanced CRISPR-Cas9 technology, ensuring high specificity and efficiency in gene targeting. By analyzing these knockout cell lines, researchers can elucidate the underlying mechanisms of APOH in lipid transport, coagulation, and how its dysfunction may lead to various diseases, including thrombotic disorders.
The scientific importance of this product lies in its wide-ranging applications in both research and clinical settings. Researchers studying dyslipidemia, autoimmune diseases, and cardiovascular pathology can utilize these cell lines for drug discovery, biomarker identification, or to validate therapeutic targets. Additionally, understanding APOH's role in these conditions opens avenues for innovative treatment strategies and personalized medicine approaches.
Compared to traditional cell lines, which may express the APOH gene, these knockout models provide a clearer insight into the gene's functions and the consequent biological effects. This specificity enhances the reproducibility and accuracy of experimental results, making them indispensable tools for researchers aiming for high-quality, reliable data.
The APOH Gene Knockout Cell Lines offered by our company provide tremendous value to researchers and clinicians alike by enabling them to explore the complexities of APOH-related biology with unprecedented precision. Our dedication to quality assurance and adherence to the latest molecular techniques ensures that these products meet the rigorous demands of modern research. With years of expertise in genetic engineering and a commitment to advancing biological research tools, our company is a trusted partner in scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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