Home / APLP1 Knockout Cell Lines

APLP1 Knockout Cell Lines

Gene: APLP1

Official Full Name: amyloid beta precursor like protein 1provided by HGNC

Gene Summary: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03670 APLP1 Knockout cell line (HeLa) Human APLP1 1:3~1:6 Negative Online Inquiry
KO03671 APLP1 Knockout cell line (HCT 116) Human APLP1 1:2~1:4 Negative Online Inquiry
KO03672 APLP1 Knockout cell line (HEK293) Human APLP1 1:3~1:6 Negative Online Inquiry
KO03673 APLP1 Knockout cell line (A549) Human APLP1 1:3~1:4 Negative Online Inquiry

Background

APLP1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disable the APLP1 gene, a member of the amyloid precursor protein (APP) family. This product facilitates in-depth exploration of the gene's physiological roles and implications in various biological processes, notably in neurodegenerative diseases. By employing CRISPR/Cas9 technology for gene editing, APLP1 Gene Knockout Cell Lines provide a powerful tool for researchers to investigate signal transduction pathways, synapse formation, and neurodevelopmental dynamics related to Alzheimer's disease and other related conditions.

The primary mechanism underlying the functionality of these knockout cell lines is the complete ablation of the APLP1 gene, which allows for the assessment of compensatory mechanisms or alternative pathways. Researchers can deploy these cell lines in high-throughput screenings to identify novel therapeutic targets, assess drug efficacy, and elucidate the molecular consequences of APLP1 deletion. This is particularly relevant in the context of Alzheimer's pathology where disruptions in APP processing have been implicated.

The scientific importance of APLP1 Gene Knockout Cell Lines lies in their capacity to advance our understanding of neurobiology, making them invaluable in both basic and applied research. These cell lines support a variety of applications in drug discovery, neurobiology, and pathology studies, presenting a vital resource for both academic institutions and pharmaceutical companies.

One distinct advantage of APLP1 Gene Knockout Cell Lines, compared to traditional knockout models or chemical inhibition approaches, is their accessibility and reliability. Researchers benefit from consistency in results across experiments due to the stable genetic alterations, eliminating variability seen in transient knockdown approaches. Our APLP1 Gene Knockout Cell Lines offer an immediate advantage for those looking to perform mechanistic studies in a controllable environment.

By choosing APLP1 Gene Knockout Cell Lines, researchers are empowered with a precise tool that not only enhances research quality but also accelerates discovery timelines. As a leading provider of innovative biotechnological products, our commitment to quality ensures that you will receive cell lines that are thoroughly characterized and validated for your research applications, bringing you one step closer to breakthroughs in science and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.