Gene: AP2A1
Official Full Name: adaptor related protein complex 2 subunit alpha 1provided by HGNC
Gene Summary: This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00470 | AP2A1 Knockout cell line (HeLa) | Human | AP2A1 | 1:3~1:6 | Negative | Online Inquiry |
KO00471 | AP2A1 Knockout cell line (A549) | Human | AP2A1 | 1:3~1:4 | Negative | Online Inquiry |
KO39096 | AP2A1 Knockout cell line (HCT 116) | Human | AP2A1 | 1:2~1:4 | Negative | Online Inquiry |
KO39097 | AP2A1 Knockout cell line (HEK293) | Human | AP2A1 | 1:3~1:6 | Negative | Online Inquiry |
AP2A1 Gene Knockout Cell Lines are a cutting-edge tool designed for advanced genetic research, representing a key innovation in the field of functional genomics. These cell lines are specifically engineered to lack the AP2A1 gene, which encodes a subunit of the adaptor protein complex 2 (AP-2), pivotal in clathrin-mediated endocytosis and intracellular trafficking. By disrupting this gene, researchers can dissect the multifaceted roles of AP-2 in cellular processes and gain insights into its implications in various diseases, including cancer and neurodegenerative conditions.
The primary function of these knockout cell lines is to facilitate comprehensive studies on the role of AP2A1 in cellular signaling and transport mechanisms. Without the presence of AP2A1, researchers can examine alterations in endocytic pathways, gene expression profiles, and protein interactions. This manipulation allows scientists to explore how the absence of AP2A1 affects cellular homeostasis and can lead to novel discoveries regarding the molecular underpinnings of disease processes.
In terms of scientific importance, AP2A1 Gene Knockout Cell Lines serve as invaluable models for investigating the implications of AP-2 deficiencies in pathological conditions. Their applications extend from basic research to translational medicine, where understanding the mechanisms of AP-2 can inform therapeutic strategies aimed at disrupting disease-associated endocytic pathways.
What sets these knockout cell lines apart from traditional models is their precision and reliability, ensuring reproducibility in experimental outcomes. Moreover, they provide an unparalleled opportunity for high-throughput screening and drug discovery, significantly reducing the time and resources typically required to obtain relevant biological data.
For researchers and clinicians alike, AP2A1 Gene Knockout Cell Lines are invaluable in advancing our understanding of cellular dynamics and disease mechanisms, ultimately guiding the development of targeted therapies. Our company specializes in providing high-quality, genetically modified cell lines, backed by years of expertise in genetic engineering and molecular biology. This commitment to excellence ensures that our products contribute significantly to the success of your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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