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AOPEP Knockout Cell Lines

Gene: AOPEP

Official Full Name: aminopeptidase O (putative)provided by HGNC

Gene Summary: This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24489 AOPEP Knockout cell line (HeLa) Human AOPEP 1:3~1:6 Negative Online Inquiry
KO24490 AOPEP Knockout cell line (HCT 116) Human AOPEP 1:2~1:4 Negative Online Inquiry
KO24491 AOPEP Knockout cell line (HEK293) Human AOPEP 1:3~1:6 Negative Online Inquiry
KO24492 AOPEP Knockout cell line (A549) Human AOPEP 1:3~1:4 Negative Online Inquiry

Background

AOPEP Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of the Alanyl-oligopeptidase (AOPEP) gene's functions and pathways. These cell lines are created using cutting-edge CRISPR-Cas9 technology, which enables precise deletion or modification of the AOPEP gene, resulting in a loss-of-function model that allows researchers to dissect the biological roles of AOPEP in various physiological and pathological contexts.

The primary function of AOPEP is to hydrolyze small peptides, thereby participating in protein metabolism and influencing various signaling pathways. By utilizing these knockout cell lines, researchers can investigate the downstream effects of AOPEP deficiency on cellular processes, such as metabolism, immune response, and cell proliferation. The ability to manipulate the AOPEP gene provides a unique opportunity to explore its role in disease models, particularly in metabolic disorders and cancers where peptide homeostasis is disrupted.

The scientific importance of AOPEP Gene Knockout Cell Lines lies in their ability to elucidate the functional implications of AOPEP in vivo and in vitro. They serve as powerful tools for drug development and biomarker discovery, enabling clinicians and researchers to identify novel therapeutic targets and understand disease mechanisms more thoroughly.

Compared to alternatives, such as transient transfection or other gene silencing methods, these knockout cell lines offer a stable and reproducible model that ensures consistent results across experiments. Researchers can confidently utilize these cell lines knowing they provide a reliable system for long-term studies without the confounding effects of transient expression.

For researchers and clinicians focused on advancing their understanding of peptide metabolism and its implications in health and disease, AOPEP Gene Knockout Cell Lines represent a valuable resource. They enable insightful experimentation and foster innovation in therapeutic development.

Our company specializes in the production of high-quality, genetically engineered cell lines, and we are committed to empowering the research community with robust, scientifically validated tools that enhance the understanding of complex biological systems. With our expertise and dedication to quality, we continue to support groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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