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ANAPC7 Knockout Cell Lines

Gene: ANAPC7

Official Full Name: anaphase promoting complex subunit 7provided by HGNC

Gene Summary: This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22545 ANAPC7 Knockout cell line (HeLa) Human ANAPC7 1:3~1:6 Negative Online Inquiry
KO22546 ANAPC7 Knockout cell line (HCT 116) Human ANAPC7 1:2~1:4 Negative Online Inquiry
KO22547 ANAPC7 Knockout cell line (HEK293) Human ANAPC7 1:3~1:6 Negative Online Inquiry
KO22548 ANAPC7 Knockout cell line (A549) Human ANAPC7 1:3~1:4 Negative Online Inquiry

Background

ANAPC7 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the ANAPC7 gene, a crucial component of the anaphase-promoting complex/cyclosome (APC/C). This gene plays a significant role in regulating the cell cycle by mediating the degradation of cyclins and other proteins pivotal for the transition from metaphase to anaphase, thus ensuring proper chromosomal segregation. The knockout technique employed in the generation of these cell lines utilizes CRISPR-Cas9 technology, enabling precise genomic alterations that facilitate the study of the functional consequences of ANAPC7 loss.

The primary function of ANAPC7 Gene Knockout Cell Lines is to provide researchers with a powerful tool for investigating the role of ANAPC7 in various cellular processes, including cell cycle regulation, mitosis, and apoptosis. By studying these knockout lines, researchers can elucidate the pathways affected by the absence of ANAPC7, contributing to a deeper understanding of cancer biology, genomic stability, and other proliferative disorders.

Scientifically, the importance of these cell lines lies in their potential applications across a wide range of research and clinical settings. They can be utilized in drug discovery and development, especially in assessing the impact of therapeutic compounds on cell cycle dynamics. Moreover, researchers can leverage these models to explore genetic interactions and identify novel pathways involved in cellular responses to various stimuli.

What sets ANAPC7 Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility. Unlike traditional knockout techniques that may result in off-target effects or variable expression, our cell lines offer a precise genetic modification, allowing for confidence in experimental outcomes. Furthermore, they are designed to be easily adaptable for high-throughput screening applications, making them suitable for both basic and applied research.

For researchers and clinicians alike, the value of ANAPC7 Gene Knockout Cell Lines cannot be overstated. They not only facilitate groundbreaking discoveries in cell biology and cancer research but also expedite the translation of these findings into therapeutic innovations.

At [Your Company Name], we are committed to advancing scientific knowledge through our expertise in developing high-quality biological products. Our ANAPC7 Gene Knockout Cell Lines exemplify this dedication, providing the tools necessary to drive progress in cellular research.

Please note that all services are for research use only. Not intended for any clinical use.

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