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ANAPC13 Knockout Cell Lines

Gene: ANAPC13

Official Full Name: anaphase promoting complex subunit 13provided by HGNC

Gene Summary: This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28732 ANAPC13 Knockout cell line (HeLa) Human ANAPC13 1:3~1:6 Negative Online Inquiry
KO28733 ANAPC13 Knockout cell line (HCT 116) Human ANAPC13 1:2~1:4 Negative Online Inquiry
KO28734 ANAPC13 Knockout cell line (HEK293) Human ANAPC13 1:3~1:6 Negative Online Inquiry
KO28735 ANAPC13 Knockout cell line (A549) Human ANAPC13 1:3~1:4 Negative Online Inquiry

Background

ANAPC13 Gene Knockout Cell Lines are specialized, genetically modified cell lines that have undergone targeted gene disruption to investigate the role of the ANAPC13 gene, which is a crucial component of the Anaphase-Promoting Complex (APC). This complex is essential for regulating the cell cycle and ensuring proper chromosomal segregation during cell division. The knockout of the ANAPC13 gene allows researchers to study its specific contributions to these vital processes, thus providing critical insights into cellular mechanisms.

The primary function of ANAPC13 knockout cell lines is to elucidate the pathways and outcomes associated with impaired APC activity. By rendering the ANAPC13 gene non-functional, these cell lines facilitate the exploration of its impacts on processes like mitotic progression, DNA damage responses, and cell fate determination. This is particularly relevant in cancer research, where dysregulation in cell cycle control can lead to tumorigenesis. Scientists can therefore utilize these cell lines to assess drug responses, investigate potential therapeutic targets, and understand the molecular underpinnings of various diseases.

In terms of scientific importance, ANAPC13 knockout cell lines serve as an invaluable resource in both basic and translational research. They are particularly beneficial in elucidating the mechanism of action of novel therapeutics aimed at cell cycle regulation. Compared to traditional methods of gene silencing or overexpression, the knockout approach provides a more definitive understanding of gene function, offering clearer phenotypic outcomes.

Uniquely, these cell lines are rigorously validated to ensure precision and reproducibility, addressing common pitfalls associated with non-specific gene editing techniques. Their unique selling point lies in their ability to provide a model that accurately mirrors the biological consequences of ANAPC13 gene ablation, enabling researchers to draw more reliable conclusions from their studies.

For researchers and clinicians alike, ANAPC13 gene knockout cell lines represent a powerful tool to enhance understanding of cell cycle regulation and its implications in oncogenesis. Their accessibility and relevance render them an essential addition to any laboratory focusing on cancer biology or cell cycle research.

At [Company Name], we pride ourselves on our expertise in creating high-quality biological products and genetically modified models that support cutting-edge research and clinical applications. Our commitment to quality ensures that our offerings meet the highest standards in the scientific community, empowering researchers to achieve breakthrough discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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