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AMMECR1 Knockout Cell Lines

Gene: AMMECR1

Official Full Name: AMMECR nuclear protein 1provided by HGNC

Gene Summary: The exact function of this gene is not known, however, submicroscopic deletion of the X chromosome including this gene, COL4A5, and FACL4 genes, result in a contiguous gene deletion syndrome, the AMME complex (Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32461 AMMECR1 Knockout cell line (HeLa) Human AMMECR1 1:3~1:6 Negative Online Inquiry
KO32462 AMMECR1 Knockout cell line (HCT 116) Human AMMECR1 1:2~1:4 Negative Online Inquiry
KO32463 AMMECR1 Knockout cell line (HEK293) Human AMMECR1 1:3~1:6 Negative Online Inquiry
KO32464 AMMECR1 Knockout cell line (A549) Human AMMECR1 1:3~1:4 Negative Online Inquiry

Background

AMMECR1 Gene Knockout Cell Lines are engineered cellular models designed to provide researchers with robust tools for studying the function of the AMMECR1 gene, implicated in various pathological conditions. These cell lines have been meticulously developed using CRISPR/Cas9 technology, which allows for precise gene editing that results in the complete knockout of the AMMECR1 gene, providing a powerful platform for functional genomics studies.

The primary mechanism by which these knockout cell lines operate involves the targeted disruption of the AMMECR1 gene, enabling researchers to investigate the resulting phenotypic changes and underlying molecular pathways. This allows for in-depth exploration into the gene's role in cellular processes such as proliferation, differentiation, and response to external stimuli. Furthermore, the absence of functional AMMECR1 facilitates the study of related signaling pathways, potentially revealing new therapeutic targets.

The scientific importance of AMMECR1 Gene Knockout Cell Lines lies in their application across both research and clinical settings. They can be utilized in drug screening, gene therapy research, and the investigation of genetic diseases, making them invaluable for labs aiming to explore gene function or develop novel interventions. Compared to traditional methods of gene knockout, the CRISPR/Cas9 system provides a more efficient, cost-effective, and reliable approach, significantly accelerating the research timeline.

One of the unique selling points of our AMMECR1 Gene Knockout Cell Lines is their high specificity and low off-target effects, ensuring that results are both reproducible and credible. Moreover, these cell lines are available in various background systems, allowing for versatile applications tailored to the specific needs of the research community.

For researchers and clinicians, the value of this product is immense; it opens doors to new discoveries that could lead to advancements in understanding disease mechanisms and the development of innovative treatments. With a commitment to quality and cutting-edge technologies, our company leverages extensive expertise in genetic editing and cell line development to provide top-tier biological products that fulfill the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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