Gene: AMFR
Official Full Name: autocrine motility factor receptorprovided by HGNC
Gene Summary: This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04157 | AMFR Knockout cell line (HeLa) | Human | AMFR | 1:3~1:6 | Negative | Online Inquiry |
KO04158 | AMFR Knockout cell line (HCT 116) | Human | AMFR | 1:2~1:4 | Negative | Online Inquiry |
KO04159 | AMFR Knockout cell line (HEK293) | Human | AMFR | 1:3~1:6 | Negative | Online Inquiry |
KO04160 | AMFR Knockout cell line (A549) | Human | AMFR | 1:3~1:4 | Negative | Online Inquiry |
Amfr Gene Knockout Cell Lines are a cutting-edge biological tool designed for advanced research in cellular and molecular biology. These cell lines are engineered to specifically lack the expression of the Amfr (Autocrine Motility Factor Receptor) gene, allowing researchers to investigate the role of this receptor in various physiological and pathological processes. By utilizing CRISPR-Cas9 technology or other gene-editing techniques, these cell lines create a precise and stable knockout of the Amfr gene, enabling detailed exploration into its functions in different biological systems.
The primary mechanism through which Amfr Gene Knockout Cell Lines operate involves the elimination of the signaling pathways that would typically be activated by the Amfr receptor. Researchers can utilize these cell lines to analyze cellular behaviors such as migration, proliferation, and apoptosis, particularly in studies related to cancer metastasis or immune response. The ability to closely examine the impact of Amfr absence on cellular processes provides insight into its role in various diseases, making this product a vital asset for both in vitro and in vivo studies in medical and pharmaceutical research.
In clinical and research settings, the Amfr Gene Knockout Cell Lines offer significant advantages over traditional model systems or non-targeted approaches. With a focus on specificity, these cell lines enhance reproducibility and accuracy in experimental results. They allow scientists to pinpoint the effects of the Amfr protein on various signaling cascades, providing a deeper comprehension of its functions that can inform therapeutic interventions or drug development.
For researchers and clinicians, the utility of these knockout cell lines lies in their capability to facilitate groundbreaking discoveries that can lead to innovative treatments, particularly in the realm of oncology and immunotherapy. By integrating the Amfr Gene Knockout Cell Lines into their research, users can accelerate the pace of scientific inquiry while obtaining data that is both robust and actionable.
Our company specializes in advanced genetic engineering products, providing high-quality cell lines and bespoke solutions tailored to the needs of the scientific community. With comprehensive support and a commitment to excellence, we are dedicated to empowering researchers to achieve their scientific goals with our innovative offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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