Gene: AKT2
Official Full Name: AKT serine/threonine kinase 2provided by HGNC
Gene Summary: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01353 | AKT2 Knockout cell line (HeLa) | Human | AKT2 | 1:3~1:6 | Negative | Online Inquiry |
KO11333 | AKT2 Knockout cell line (HCT 116) | Human | AKT2 | 1:2~1:4 | Negative | Online Inquiry |
KO11334 | AKT2 Knockout cell line (HEK293) | Human | AKT2 | 1:3~1:6 | Negative | Online Inquiry |
KO11335 | AKT2 Knockout cell line (A549) | Human | AKT2 | 1:3~1:4 | Negative | Online Inquiry |
AKT2 Gene Knockout Cell Lines are meticulously engineered cellular models that contain targeted deletions of the AKT2 gene, a critical component of the AKT signaling pathway involved in various cellular processes such as metabolism, growth, and survival. By utilizing CRISPR-Cas9 gene editing technology, these cell lines demonstrate how the absence of AKT2 affects numerous biological functions, making them invaluable tools for probing the molecular mechanisms underlying diverse pathologies, particularly cancer and metabolic disorders.
The primary mechanism by which these knockout cell lines operate involves the elimination of AKT2 expression, leading to altered downstream signaling cascades. This disruption allows researchers to investigate AKT2's role in cell proliferation, apoptosis, and glucose metabolism, as well as its interactions with other signaling proteins. The ability to create a controlled environment where specific genes are rendered inactive enables detailed functional analysis, providing insights that can influence therapeutic strategy development.
AKT2 Gene Knockout Cell Lines hold significant scientific importance in both research and clinical settings. They offer critical insights for identifying potential drug targets and understanding tumor biology, as dysregulation of the AKT pathway is frequently implicated in oncogenesis. Furthermore, these cell lines aid in the discovery of novel therapeutic agents aimed at restoring normal signaling pathways disrupted by AKT2 mutations.
Compared to traditional models, such as whole-animal studies or chemical inhibition methods, our AKT2 Gene Knockout Cell Lines provide a precise and reproducible system that minimizes biological variability. Their specificity allows for targeted experimentation, providing a clearer understanding of the gene's function without the confounding effects of other cellular processes.
For researchers and clinicians striving to innovate in cancer research or metabolic studies, the AKT2 Gene Knockout Cell Lines present a unique solution that enhances experimental accuracy and depth. By choosing our cell lines, users gain access to high-quality models underpinned by rigorous validation, facilitating impactful research outcomes.
With a commitment to advancing biological understanding, our company specializes in providing state-of-the-art genetic and cellular products that empower scientists to explore complex biological systems effectively.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.