Gene: AHNAK2
Official Full Name: AHNAK nucleoprotein 2provided by HGNC
Gene Summary: This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00314 | AHNAK2 Knockout cell line(A549) | Human | AHNAK2 | 1:3~1:4 | Negative | Online Inquiry |
KO05691 | AHNAK2 Knockout cell line (HeLa) | Human | AHNAK2 | 1:3~1:6 | Negative | Online Inquiry |
KO05692 | AHNAK2 Knockout cell line (HCT 116) | Human | AHNAK2 | 1:2~1:4 | Negative | Online Inquiry |
AHNAK2 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology and genetic research, designed specifically to provide researchers with the ability to investigate the functional role of the AHNAK2 gene. AHNAK2, which encodes a large scaffold protein involved in cell signaling, cytoskeletal organization, and cellular response processes, has been implicated in various physiological functions and diseases. These knockout cell lines facilitate a targeted loss of function analysis, allowing scientists to observe phenotypic changes associated with the absence of AHNAK2 expression.
The key mechanism of these cell lines lies in the CRISPR/Cas9 genome-editing technology that enables precise, site-specific modifications to the genomic DNA. By introducing a double-strand break within the target AHNAK2 gene and leveraging the cell’s natural DNA repair processes, researchers can create stable knockout variants. This results in invaluable insights into how AHNAK2 contributes to cell motility, proliferation, and overall cellular dynamics, particularly in cancer biology and neurodegenerative research.
The scientific importance of AHNAK2 Gene Knockout Cell Lines is underscored by the growing body of evidence linking AHNAK2 to critical pathways involved in disease mechanisms. These cell lines are particularly valuable for researchers seeking to understand the gene's role in malignant transformation and could serve as a platform for screening potential therapeutic interventions. Furthermore, their application extends to drug development and biomarker discovery, positioning researchers at the forefront of innovative therapeutic strategies.
One of the main advantages of our AHNAK2 Gene Knockout Cell Lines is the high efficiency of gene editing employed, ensuring reproducible results that enhance the reliability of experimental outcomes. Additionally, these cell lines come with the assurance of comprehensive characterization and validation against common cellular markers, a feature that distinguishes them from other less rigorously tested alternatives available in the market.
For researchers and clinicians focused on exploring the underlying mechanisms of disease or developing targeted therapeutics, these knockout cell lines provide a unique opportunity to generate insights that could lead to significant advancements in clinical practice and personalized medicine. Our company prides itself on its expertise in cellular models and genetic engineering, offering a suite of reliable products that empower scientists to achieve their research goals effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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