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AGPAT1 Knockout Cell Lines

Gene: AGPAT1

Official Full Name: 1-acylglycerol-3-phosphate O-acyltransferase 1provided by HGNC

Gene Summary: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07741 AGPAT1 Knockout cell line (HeLa) Human AGPAT1 1:3~1:6 Negative Online Inquiry
KO07742 AGPAT1 Knockout cell line (HCT 116) Human AGPAT1 1:2~1:4 Negative Online Inquiry
KO07743 AGPAT1 Knockout cell line (HEK293) Human AGPAT1 1:3~1:6 Negative Online Inquiry
KO07744 AGPAT1 Knockout cell line (A549) Human AGPAT1 1:3~1:4 Negative Online Inquiry

Background

AGPAT1 Gene Knockout Cell Lines are specialized research tools designed to facilitate the study of the AGPAT1 gene, which encodes an enzyme critical in the biosynthesis of glycerolipids. By creating a knockout of the AGPAT1 gene, these cell lines allow researchers to investigate its biological functions, contributing to our understanding of lipid metabolism and related disorders.

The primary mechanism of these knockout cell lines involves the disruption of the AGPAT1 gene, leading to the loss of function of the AGPAT1 protein. This loss provides an invaluable opportunity to analyze altered lipid profiles, modifications in cell signaling pathways, and the broader impact on cellular metabolism. Researchers can employ these cell lines to explore pathological conditions associated with AGPAT1 dysregulation, such as obesity, insulin resistance, and other metabolic syndromes.

The scientific importance of AGPAT1 Gene Knockout Cell Lines extends to both basic research and clinical settings. They are instrumental in identifying potential therapeutic targets for metabolic diseases and studying the biochemical pathways influenced by glycerolipid synthesis. Furthermore, these cell lines can be applied in drug discovery processes, aiding in the evaluation of novel therapeutic agents aimed at rectifying AGPAT1-linked dysfunction.

Compared to traditional cell lines, AGPAT1 Gene Knockout Cell Lines present a significant advantage as they provide a more accurate model for studying the specific effects of AGPAT1 loss. This targeted approach allows for more precise experimental outcomes, reducing the variability often seen in studies using conventional models.

For researchers, clinicians, and pharmaceutical developers, AGPAT1 Gene Knockout Cell Lines represent a critical asset in advancing scientific knowledge and therapeutic innovation. Their unique ability to mimic pathological conditions linked to AGPAT1 makes them indispensable for high-quality research.

Our company prides itself on its commitment to excellence in biotechnological products, backed by extensive expertise in genetic engineering and cellular biology. We are dedicated to providing researchers with reliable tools that enhance experimental accuracy and contribute significantly to scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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