Gene: AGAP2
Official Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08201 | AGAP2 Knockout cell line (HCT 116) | Human | AGAP2 | 1:2~1:4 | Negative | Online Inquiry |
KO08202 | AGAP2 Knockout cell line (HEK293) | Human | AGAP2 | 1:3~1:6 | Negative | Online Inquiry |
AGAP2 Gene Knockout Cell Lines are a specialized set of cellular models wherein the AGAP2 gene has been inactivated through targeted gene editing techniques, primarily CRISPR-Cas9. These engineered cell lines provide invaluable tools for studying the biological functions of the AGAP2 protein, a member of the Arf GAP family, which is implicated in various cellular processes including endocytosis, signaling pathways, and cytoskeletal dynamics.
The key function of AGAP2 revolves around its role in modulating the activity of small GTPases, thereby influencing vesicle trafficking and membrane organization. By creating knockout cell lines, researchers are able to precisely dissect the molecular pathways that AGAP2 governs, facilitating understanding of its contribution to physiological and pathological states, such as cancer progression or neurodegenerative diseases.
The scientific importance of AGAP2 Gene Knockout Cell Lines is underscored by their diverse applications in both basic and translational research. These lines enable researchers to explore gene function in cellular models that more accurately recapitulate the in vivo environment, greatly enhancing the validity of findings. In clinical settings, they have the potential to aid in the development of novel therapeutic strategies targeting AGAP2-related mechanisms, thus paving the way for improved treatment options.
One of the standout advantages of our AGAP2 Gene Knockout Cell Lines is the quality of the gene editing, which minimizes off-target effects, offering high specificity unlike competitors. Additionally, these cell lines are derived from various human tissues, allowing flexibility in experimentation to best suit diverse research needs.
For researchers and clinicians, the value of AGAP2 Gene Knockout Cell Lines lies in their contribution to advancing knowledge on critical genes involved in disease pathways, ultimately fostering innovative solutions to complex medical challenges. Our company specializes in providing high-quality biological products, backed by a commitment to scientific excellence and customer support, ensuring that our users can rely on our expertise to facilitate their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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