Home / ADH5 Knockout Cell Lines

ADH5 Knockout Cell Lines

Gene: ADH5

Official Full Name: alcohol dehydrogenase 5 (class III), chi polypeptideprovided by HGNC

Gene Summary: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39106 ADH5 Knockout cell line (HeLa) Human ADH5 1:3~1:6 Negative Online Inquiry
KO39107 ADH5 Knockout cell line (HCT 116) Human ADH5 1:2~1:4 Negative Online Inquiry
KO39108 ADH5 Knockout cell line (HEK293) Human ADH5 1:3~1:6 Negative Online Inquiry
KO39109 ADH5 Knockout cell line (A549) Human ADH5 1:3~1:4 Negative Online Inquiry

Background

ADH5 Gene Knockout Cell Lines are essential research tools designed to study the specific biological roles played by the alcohol dehydrogenase 5 (ADH5) enzyme in various metabolic processes. These cell lines have been genetically engineered to lack functional ADH5, allowing for precise investigations into the enzyme's contributions to alcohol metabolism, oxidative stress, and other biochemical pathways.

The primary function of these knockout cell lines is to provide a controlled environment for researchers to analyze the consequences of ADH5 deficiency on cellular behavior, gene expression, and metabolic regulation. By comparing these knockout cells with wild-type controls, scientists can unravel the mechanisms by which ADH5 influences key physiological processes, including the metabolism of ethanol and the detoxification of aldehydes. This insight is particularly valuable for understanding alcohol-related diseases and developing therapeutic strategies.

ADH5 Gene Knockout Cell Lines serve as powerful models in both fundamental research and translational science. In clinical research settings, they can facilitate the examination of individual variability in drug metabolism and susceptibility to alcohol-induced harm. The ability to directly observe the functional effects of ADH5 deletion paves the way for novel drug discoveries and personalized medicine approaches in treating metabolic disorders.

What sets our ADH5 Gene Knockout Cell Lines apart is their high specificity, reproducibility, and the extensive characterization that includes validation of genetic modification and metabolic profiling. Unlike other models, our cell lines come with comprehensive user guides and experimental support, ensuring researchers can achieve their project goals more efficiently.

In summary, these knockout cell lines are invaluable for advancing our comprehension of metabolic processes involving ADH5, offering numerous applications in research and clinical settings. Our company, backed by a team of expert geneticists and molecular biologists, is dedicated to providing high-quality biological products that empower researchers to push the boundaries of knowledge in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.