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ADGRL3 Knockout Cell Lines

Gene: ADGRL3

Official Full Name: adhesion G protein-coupled receptor L3provided by HGNC

Gene Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29526 ADGRL3 Knockout cell line (HEK293) Human ADGRL3 1:3~1:6 Negative Online Inquiry

Background

ADGRL3 Gene Knockout Cell Lines are specialized cellular models engineered to facilitate the study of the Adhesion G Protein-Coupled Receptor L3 (ADGRL3), also known as latrophilin-3. This gene plays a critical role in various cellular processes, including synaptic function, cell adhesion, and neurodevelopment. By knocking out ADGRL3, these cell lines provide a valuable tool for researchers investigating the gene's specific functions and its implications in neurological disorders, such as autism spectrum disorders and anxiety-related conditions.

The primary mechanism of action for these knockout cell lines involves the complete disruption of ADGRL3 expression, enabling researchers to observe the cascading effects on associated signaling pathways, cellular morphology, and function. This allows for a detailed analysis of the gene's contribution to cellular processes, thus advancing our understanding of its role in health and disease.

In research and clinical settings, ADGRL3 Gene Knockout Cell Lines hold significant importance as they enable high-throughput screening for potential therapeutic targets, validation of drug efficacy, and investigation of pathophysiological mechanisms linked to ADGRL3. These cell lines can be utilized in various applications, including neurobiological studies, pharmacological research, and gene therapy development.

Compared to conventional approaches, such as RNA interference or chemical inhibition, ADGRL3 Gene Knockout Cell Lines offer several unique selling points. They provide a stable and permanent model for studying the gene's impact without the variability often associated with transient knockdown techniques. Moreover, their specificity allows for the isolation of ADGRL3's effects from other signaling pathways, leading to more robust and reproducible experimental outcomes.

For researchers and clinicians, the use of these specialized cell lines represents a significant advancement in the quest to understand complex neurological conditions. They offer an unparalleled opportunity to dissect the molecular underpinnings of diseases linked to ADGRL3, ultimately leading to the development of more effective therapeutic strategies.

Our company is committed to delivering high-quality, scientifically validated biological products, and our ADGRL3 Gene Knockout Cell Lines exemplify our dedication to advancing research and fostering innovation in the life sciences. With our expertise in genetic engineering and cell line development, we aim to support your research endeavors and contribute to breakthroughs in medical science.

Please note that all services are for research use only. Not intended for any clinical use.

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