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ADGRA2 Knockout Cell Lines

Gene: ADGRA2

Official Full Name: adhesion G protein-coupled receptor A2provided by HGNC

Gene Summary: Predicted to enable G protein-coupled receptor activity. Involved in canonical Wnt signaling pathway. Located in intracellular membrane-bounded organelle and plasma membrane. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28559 ADGRA2 Knockout cell line (HeLa) Human ADGRA2 1:3~1:6 Negative Online Inquiry
KO28560 ADGRA2 Knockout cell line (HCT 116) Human ADGRA2 1:2~1:4 Negative Online Inquiry
KO28561 ADGRA2 Knockout cell line (HEK293) Human ADGRA2 1:3~1:6 Negative Online Inquiry

Background

ADGRA2 Gene Knockout Cell Lines are genetically modified cell lines engineered to have a complete knockout of the ADGRA2 gene, which encodes a crucial protein implicated in various signaling pathways affecting cellular adhesion and communication. These cell lines serve as a valuable tool for researchers aiming to explore the functional roles of ADGRA2 in physiological and pathological processes, including cancer progression, inflammation, and neurological disorders.

The key functionality of these cell lines lies in their ability to facilitate the investigation of ADGRA2's role in signal transduction. By offering insights into the molecular pathways modulated by ADGRA2, researchers can elucidate mechanisms of cell signaling that affect cell behavior, tissue development, and disease manifestation. The knockout effectively creates a loss-of-function model, providing a direct approach to assess changes in cellular responses, such as migration, proliferation, and differentiation.

Scientific applications of ADGRA2 Gene Knockout Cell Lines extend to both basic and applied research. In clinical settings, these lines can aid in drug discovery and therapeutic intervention strategies by revealing potential targets for pharmacological modulation. They are particularly significant in understanding disorders where ADGRA2 is suggested to have a pathological role.

Compared to alternative methods, such as transient knockdown techniques or less stable gene editing methods, the ADGRA2 Gene Knockout Cell Lines offer greater stability and reproducibility in experiments. This stability is critical for longitudinal studies, where consistent gene expression levels are paramount. Furthermore, the robust nature of these knockout lines simplifies the experimental design by allowing researchers to assess the effects of abolishing ADGRA2 function in diverse biological contexts.

Researchers and clinicians will find great value in the ADGRA2 Gene Knockout Cell Lines due to their capability to provide unequivocal evidence of gene function, paving the way for novel therapeutic approaches. This product is a testament to our company's commitment to providing high-quality, innovative tools tailored for cutting-edge scientific investigation. With extensive expertise in the development of genetic models, we empower researchers to unlock new frontiers in biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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