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ADCK1 Knockout Cell Lines

Gene: ADCK1

Official Full Name: aarF domain containing kinase 1provided by HGNC

Gene Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19992 ADCK1 Knockout cell line (HeLa) Human ADCK1 1:3~1:6 Negative Online Inquiry
KO19993 ADCK1 Knockout cell line (HCT 116) Human ADCK1 1:2~1:4 Negative Online Inquiry
KO19994 ADCK1 Knockout cell line (HEK293) Human ADCK1 1:3~1:6 Negative Online Inquiry
KO19995 ADCK1 Knockout cell line (A549) Human ADCK1 1:3~1:4 Negative Online Inquiry

Background

ADCK1 Gene Knockout Cell Lines are engineered cellular models created specifically to study the functions associated with the ADCK1 gene. This gene plays a critical role in mitochondrial biology; it encodes a member of the protein kinase family that is involved in the regulation of mitochondrial coenzyme Q biosynthesis. By utilizing CRISPR/Cas9 technology, the ADCK1 gene has been selectively disrupted, allowing researchers to explore the implications of its absence on cellular metabolism, oxidative stress responses, and mitochondrial integrity.

The primary function of these cell lines is to serve as a platform for investigating the pathological mechanisms underlying inherited diseases related to ADCK1, particularly those affecting mitochondrial function and energy production. By comparing the knockout cell lines with wild-type counterparts, researchers can delineate the biochemical pathways impacted by ADCK1 disruption, providing insights into potential therapeutic targets and strategies.

In both research and clinical settings, the ADCK1 Gene Knockout Cell Lines hold significant scientific importance. They offer a unique tool for drug discovery, disease modeling, and understanding the etiology of mitochondrial disorders. The ability to manipulate these cells enables detailed functional assays and high-throughput screening of compounds that may restore normal cellular function or mitigate pathogenic effects.

One of the key advantages of our ADCK1 Gene Knockout Cell Lines is their unparalleled specificity and reliability. Unlike traditional models, these engineered lines provide a more accurate representation of the effects of gene knockout on cellular physiology, reducing variability and enhancing reproducibility. Moreover, the precision brought about by the CRISPR/Cas9 methodology significantly decreases the risk of off-target effects, thereby providing a clearer understanding of gene functions.

For researchers and clinicians focused on mitochondrial diseases, the value of the ADCK1 Gene Knockout Cell Lines lies in their capability to facilitate groundbreaking scientific discoveries and advance the development of targeted interventions. These cell lines enhance the translational potential of research findings, bridging the gap between basic biology and clinical applications.

Our company is committed to providing advanced biological products that empower the scientific community. With expertise in cellular engineering and a dedication to innovation, we offer high-quality models that support your research endeavors, ultimately contributing to better health outcomes worldwide.

Please note that all services are for research use only. Not intended for any clinical use.

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