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ADAM19 Knockout Cell Lines

Gene: ADAM19

Official Full Name: ADAM metallopeptidase domain 19provided by HGNC

Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33908 ADAM19 Knockout cell line (HeLa) Human ADAM19 1:3~1:6 Negative Online Inquiry
KO33909 ADAM19 Knockout cell line (HCT 116) Human ADAM19 1:2~1:4 Negative Online Inquiry
KO33910 ADAM19 Knockout cell line (HEK293) Human ADAM19 1:3~1:6 Negative Online Inquiry
KO33911 ADAM19 Knockout cell line (A549) Human ADAM19 1:3~1:4 Negative Online Inquiry

Background

ADAM19 Gene Knockout Cell Lines are genetically engineered cellular models designed to elucidate the function of the ADAM19 gene, which encodes for a member of the ADAM (A Disintegrin and Metalloproteinase) family of proteins known for their roles in cell adhesion, proteolysis, and signaling. These cell lines are created through precise gene editing techniques, ensuring the ADAM19 gene is effectively inactivated. This knockout model allows researchers to study the implications of ADAM19 deficiency in various biological processes and disease states, particularly those related to tissue remodeling, inflammation, and tumor progression.

The key function of these knockout cell lines lies in their ability to mimic the physiological conditions of ADAM19 deficiency, allowing for detailed investigations into the molecular mechanisms at play in cellular signaling pathways. In research settings, scientists can assess how the absence of ADAM19 influences cellular behavior, including migration, proliferation, and apoptosis. The significance of ADAM19 is particularly notable in cancer research, where its role in mediating interactions between tumor cells and the extracellular matrix may offer insights into metastasis and invasion.

Compared to traditional cell lines that express the ADAM19 gene, these knockout lines provide unparalleled advantages in specificity and reliability. Researchers no longer need to rely solely on pharmacological inhibitors, which may have off-target effects. Instead, they can conduct more conclusive experiments to directly observe the biological implications of the gene's absence, leading to clearer data interpretation and more robust results.

For clinicians and researchers, ADAM19 Gene Knockout Cell Lines represent an invaluable tool in their arsenal, enabling exploration into therapeutic targets and the development of novel interventions. The availability of these models can accelerate the pace of discovery in various fields, from oncology to regenerative medicine.

Our company prides itself on its advanced capabilities in gene editing and the development of innovative biological tools. With a commitment to providing high-quality products that facilitate groundbreaking research, we ensure that our ADAM19 Gene Knockout Cell Lines meet the highest standards of scientific rigor.

Please note that all services are for research use only. Not intended for any clinical use.

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