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ACTR1A Knockout Cell Lines

Gene: ACTR1A

Official Full Name: actin related protein 1Aprovided by HGNC

Gene Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32269 ACTR1A Knockout cell line (HeLa) Human ACTR1A 1:3~1:6 Negative Online Inquiry
KO32270 ACTR1A Knockout cell line (HCT 116) Human ACTR1A 1:2~1:4 Negative Online Inquiry
KO32271 ACTR1A Knockout cell line (HEK293) Human ACTR1A 1:3~1:6 Negative Online Inquiry

Background

ACTR1A Gene Knockout Cell Lines are specialized cellular models in which the ACTR1A gene, known to encode the cytoplasmic protein involved in cellular transport and endocytosis, has been selectively disrupted. This advanced tool facilitates the study of gene function and protein interactions essential for understanding cellular dynamics. The knockout of ACTR1A provides researchers the ability to investigate the effects of its absence on various cellular processes, such as intracellular trafficking, cytoskeletal organization, and mechanotransduction.

These cell lines utilize CRISPR-Cas9 gene-editing technology that enables precise manipulation of the genome, thus creating a well-defined model for studying phenotypic changes associated with the regulation of ACTR1A. In scientific research and clinical applications, such models can be pivotal for elucidating pathways involved in various diseases, including neurodegenerative disorders and cancer, where the misregulation of transport mechanisms can significantly impact cell survival and functionality.

One of the standout advantages of ACTR1A Gene Knockout Cell Lines is their specificity and reliability. Compared to traditional knockdown strategies using RNA interference, these knockout models offer a more definitive and permanent gene disruption, enabling unequivocal results without the confounding effects of residual gene activity. Furthermore, they allow for the consistent replication of results across experiments, essential for rigorous scientific investigations.

For researchers and clinicians aiming to delve into the intricate roles of ACTR1A in health and disease, these knockout cell lines present an invaluable resource. They support a range of applications from drug discovery to basic biological research, helping to bridge the gap between understanding genetic engineering and therapeutic development.

Our company prides itself on providing high-quality biological products, backed by robust scientific expertise and cutting-edge technology, ensuring that our ACTR1A Gene Knockout Cell Lines uphold the highest standards of research integrity and innovation. This commitment empowers researchers to advance their discoveries with confidence and clarity.

Please note that all services are for research use only. Not intended for any clinical use.

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