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ACTB Knockout Cell Lines

Gene: ACTB

Official Full Name: actin betaprovided by HGNC

Gene Summary: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08694 ACTB Knockout cell line (HeLa) Human ACTB 1:3~1:6 Negative Online Inquiry
KO08695 ACTB Knockout cell line (HCT 116) Human ACTB 1:2~1:4 Negative Online Inquiry
KO08696 ACTB Knockout cell line (HEK293) Human ACTB 1:3~1:6 Negative Online Inquiry
KO08697 ACTB Knockout cell line (A549) Human ACTB 1:3~1:4 Negative Online Inquiry

Background

ACTB Gene Knockout Cell Lines are expertly engineered biological tools derived from the human or mouse genome, specifically designed to facilitate the study of cellular processes and investigate the role of the ACTB gene. This gene encodes for beta-actin, a crucial cytoskeletal protein involved in various cellular functions such as motility, structure maintenance, and cell signaling. By creating knockout models, researchers can effectively silence ACTB expression, thereby elucidating its impact on cellular dynamics and the molecular underpinnings of diseases such as cancer and neurodegeneration.

These cell lines function via targeted gene editing technologies, such as CRISPR-Cas9 or RNA interference, which selectively disrupt the ACTB gene. This allows for an in-depth analysis of the consequent phenotypic changes and provides insights into compensatory mechanisms employed by cells. The specificity of these gene knockout models makes them invaluable in both basic and applied research, ranging from drug discovery to therapeutic development.

The scientific importance of ACTB Gene Knockout Cell Lines lies not only in their capacity to model disease states but also in their role in validating therapeutic targets, enhancing our understanding of actin-associated cellular processes. Their unique selling points include robust performance metrics, reproducible results, and the ability to be utilized in a variety of experimental setups, setting them apart from conventional cell lines that may exhibit background expression of ACTB.

With a steadfast commitment to advancing scientific research, our company prides itself on delivering high-quality biological products that meet the rigorous demands of researchers and clinicians alike. Our expertise in genetic engineering and cell line development ensures that users can rely on our ACTB Gene Knockout Cell Lines for consistent, reliable data essential for making significant breakthroughs in their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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