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ABRAXAS1 Knockout Cell Lines

Gene: ABRAXAS1

Official Full Name: abraxas 1, BRCA1 A complex subunitprovided by HGNC

Gene Summary: This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25159 ABRAXAS1 Knockout cell line (HeLa) Human ABRAXAS1 1:3~1:6 Negative Online Inquiry
KO25160 ABRAXAS1 Knockout cell line (HCT 116) Human ABRAXAS1 1:2~1:4 Negative Online Inquiry
KO25161 ABRAXAS1 Knockout cell line (HEK293) Human ABRAXAS1 1:3~1:6 Negative Online Inquiry
KO25162 ABRAXAS1 Knockout cell line (A549) Human ABRAXAS1 1:3~1:4 Negative Online Inquiry

Background

ABRAXAS1 Gene Knockout Cell Lines are uniquely engineered cellular systems designed to facilitate the study of the ABRAXAS1 gene's function and its implications in various biological processes. These cell lines have been created using CRISPR-Cas9 technology, which allows for precise editing of the genome to completely disable the ABRAXAS1 gene. The resulting knockout cell lines serve as invaluable tools for researchers aiming to elucidate the gene's role in cellular pathways, including DNA repair mechanisms and oncogenesis.

The key function of the ABRAXAS1 Gene Knockout Cell Lines lies in their ability to mimic the physiological conditions of ABRAXAS1 depletion. By providing a controlled environment, researchers can investigate the consequences of gene loss on cellular behavior, proliferation rates, and response to DNA damage. This includes elucidating pathways such as the ATM/ATR signaling cascade, crucial for maintaining genome stability. The insights gained can significantly contribute to understanding cancer biology and resilience mechanisms in tumor cells.

The scientific importance of these knockout cell lines extends into both research and clinical settings. For instance, they enable drug discovery efforts by offering a model to test novel therapeutics targeting pathways influenced by ABRAXAS1. Additionally, the cell lines could support biomarker identification and therapeutic stratification for cancer patients.

Compared to alternative gene knockout strategies, the ABRAXAS1 Gene Knockout Cell Lines provide a higher degree of specificity and efficiency, ensuring minimal off-target effects, thus yielding more reliable data. They are also readily adaptable to various experiments, including high-throughput screening, making them a versatile addition to the laboratory toolkit.

For researchers and clinicians looking to deepen their understanding of the ABRAXAS1 gene's role in disease, these cell lines represent an essential resource. The advanced genetic engineering techniques used to create these knockout lines provide a robust platform for both academic and industry-oriented investigations.

At our company, we specialize in cutting-edge gene editing technologies and the development of high-quality biological products. Our commitment to providing exceptional tools like the ABRAXAS1 Gene Knockout Cell Lines underscores our expertise in supporting the scientific community with innovative solutions that drive research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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