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AACS Knockout Cell Lines

Gene: AACS

Official Full Name: acetoacetyl-CoA synthetaseprovided by HGNC

Gene Summary: Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01582 AACS Knockout cell line (HeLa) Human AACS 1:3~1:6 Negative Online Inquiry
KO01583 AACS Knockout cell line (HCT 116) Human AACS 1:2~1:4 Negative Online Inquiry
KO01584 AACS Knockout cell line (HEK293) Human AACS 1:3~1:6 Negative Online Inquiry
KO01585 AACS Knockout cell line (A549) Human AACS 1:3~1:4 Negative Online Inquiry

Background

AACS Gene Knockout Cell Lines are precisely engineered cellular models lacking the AACS (Acetoacetyl-CoA synthase) gene, pivotal for investigating metabolic pathways and cellular function. These cell lines are generated through advanced CRISPR/Cas9 technology, allowing for a targeted and efficient disruption of gene expression. By silencing the AACS gene, researchers can study its impact on lipid metabolism, energy homeostasis, and cellular response to stress, thus unlocking fundamental knowledge about metabolic diseases, cancer biology, and potential therapeutic targets.

The primary function of AACS Gene Knockout Cell Lines involves elucidating the role of AACS in various metabolic processes. Without the AACS pathway, these cells exhibit altered metabolic profiles, facilitating the study of compensatory mechanisms and the metabolic reprogramming that occurs in disease states. This models specifically designed for high-throughput screening and gene expression analysis, serve as invaluable tools in drug discovery and development, enabling scientists to test the efficacy of potential pharmacological agents under controlled conditions.

The scientific importance of using AACS Gene Knockout Cell Lines extends to clinical applications, particularly in developing strategies for treating metabolic disorders and understanding tumorigenesis. Their ability to mimic human cellular responses provides insights that are crucial for translating findings from bench to bedside. Compared to traditional models, these cell lines offer a more accurate representation of the metabolic phenotype, making them superior for both research and clinical implications.

Moreover, the unique selling points of AACS Gene Knockout Cell Lines include the flexibility in storing and maintaining cell cultures, extensive characterization information available to users, and the potential for genetic re-engineering to create tailored models for specific research needs. This versatility enables researchers to obtain reproducible and reliable data, significantly reducing the time and resources spent on earlier model systems.

For researchers and clinicians, investing in AACS Gene Knockout Cell Lines means gaining access to cutting-edge tools to drive innovation in metabolic research. This product empowers studies that can lead to novel therapeutic strategies and enhanced understanding of complex biological systems. With a commitment to excellence in biological research products, our company stands as a leader in providing high-quality, reliable cell lines, ensuring that our customers have the best resources to achieve their scientific goals.

Please note that all services are for research use only. Not intended for any clinical use.

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