HIF1A Knockout cell line (HCT 116)

Catalog Number: KO08291

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Specifications

Product Information
Product Name	HIF1A Knockout cell line (HCT 116)
specification	1*10^6
Storage and transportation	Dry ice preservation/T25 live cell transportation.
Cell morphology	Epithelioid, adherent cell
Passage ratio	1:2~1:4
species	Human
Gene	HIF1A
Gene ID	3091
Build method	Electric rotation method / virus method
Mycoplasma testing	Negative
Cultivation system	90%McCOYs 5A+10% FBS
Parental Cell Line	HCT 116
Quality Control	Genotype: HIF1A Knockout cell line (HCT 116) >95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	hypoxia inducible factor 1 subunit alphaprovided by HGNC
Also known as	HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha
Gene Description	This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Expression	Broad expression in bone marrow (RPKM 164.2), gall bladder (RPKM 101.1) and 24 other tissues See more

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