Gene: ZNF653
Official Full Name: zinc finger protein 653provided by HGNC
Gene Summary: Enables AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30569 | ZNF653 Knockout cell line (HeLa) | Human | ZNF653 | 1:3~1:6 | Negative | Online Inquiry |
KO30570 | ZNF653 Knockout cell line (HCT 116) | Human | ZNF653 | 1:2~1:4 | Negative | Online Inquiry |
KO30571 | ZNF653 Knockout cell line (HEK293) | Human | ZNF653 | 1:3~1:6 | Negative | Online Inquiry |
KO30572 | ZNF653 Knockout cell line (A549) | Human | ZNF653 | 1:3~1:4 | Negative | Online Inquiry |
ZNF653 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the in-depth study of the ZNF653 gene, a key player implicated in various biological processes and diseases. These knockout cell lines have been meticulously crafted using CRISPR/Cas9 technology, resulting in the complete disruption of the ZNF653 gene, thus providing a powerful tool for understanding the gene's functional role in cellular mechanisms and disease states.
The primary function of ZNF653 Gene Knockout Cell Lines lies in their ability to serve as a distinct platform to investigate the consequences of ZNF653 loss-of-function. Researchers can examine alterations in gene expression, cellular signaling pathways, and phenotypic changes, enabling a comprehensive analysis of the gene's involvement in processes such as cell growth, differentiation, and apoptosis. Moreover, the knockout cell lines can be employed to explore potential therapeutic targets, elucidating the gene's role in disease pathogenesis and response to treatment.
The scientific importance of these cell lines is underscored by their extensive applications in both fundamental research and clinical settings. They are invaluable for investigating genetic diseases, cancer biology, and the development of targeted therapies, thus serving as a crucial component in translational science. Additionally, they can aid in drug screening and the validation of new therapeutic strategies, making them essential for the advancement of personalized medicine.
What sets ZNF653 Gene Knockout Cell Lines apart from alternative models is their precise gene editing that ensures reliable reproducibility and specificity in experimental results. Compared to conventional gene knockdown approaches, such as RNA interference, knockout models provide a definitive and permanent alteration of the gene, thereby offering clearer insights into gene function and downstream effects.
For researchers and clinicians, the ability to manipulate ZNF653 expression provides significant value, allowing for enhanced understanding of its biological roles and implications in health and disease. This capability can expedite the discovery of novel therapeutic options and contribute to the development of tailored treatment strategies.
Our company is committed to advancing the field of genetic research through high-quality biological products like ZNF653 Gene Knockout Cell Lines, backed by years of expertise and innovation. We understand the importance of reliable and effective research tools, and we strive to equip scientists and clinicians with the resources they need to drive their discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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