Gene: ZNF451
Official Full Name: zinc finger protein 451provided by HGNC
Gene Summary: Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in PML body. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28448 | ZNF451 Knockout cell line (HeLa) | Human | ZNF451 | 1:3~1:6 | Negative | Online Inquiry |
KO28449 | ZNF451 Knockout cell line (HCT 116) | Human | ZNF451 | 1:2~1:4 | Negative | Online Inquiry |
KO28450 | ZNF451 Knockout cell line (HEK293) | Human | ZNF451 | 1:3~1:6 | Negative | Online Inquiry |
KO28451 | ZNF451 Knockout cell line (A549) | Human | ZNF451 | 1:3~1:4 | Negative | Online Inquiry |
ZNF451 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the ZNF451 gene, which is known to be involved in various regulatory processes, including transcriptional repression and chromatin remodeling. By utilizing CRISPR/Cas9 genome editing technology, these cell lines provide researchers with a powerful tool for studying the biological functions of ZNF451 and its potential implications in cellular processes such as differentiation, proliferation, and response to stress.
The primary function of ZNF451 Gene Knockout Cell Lines is to facilitate the exploration of the ZNF451 gene's role in gene expression and its contribution to disease pathways. The absence of this gene enables the observation of phenotypic changes and alterations in molecular signaling pathways, providing insights that are critical for understanding cancer biology, developmental biology, and genetic disorders. These advanced cell lines are crucial for researchers seeking to dissect the complex mechanisms of gene regulation and to evaluate potential therapeutic targets.
One of the unique advantages of ZNF451 Gene Knockout Cell Lines is their high specificity and efficiency in gene disruption, which surpasses traditional methods such as siRNA or shRNA approaches. Additionally, these cell lines are readily available for various research applications, encompassing both in vitro experimental setups and drug discovery processes. They enable reproducible results due to their well-characterized genetic background, thus ensuring reliable data for extensive research endeavors.
The value of ZNF451 Gene Knockout Cell Lines is particularly profound for researchers and clinicians focused on genomic studies and translational research. Their ability to model disease states and test hypotheses in a controlled environment directly correlates with advancements in personalized medicine and targeted therapies.
With a commitment to scientific excellence, our company prides itself on providing high-quality biological products that are developed through rigorous validation processes and continuous innovation. We aim to support the research community by delivering tools that drive forward discoveries in genetics and molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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