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ZDHHC9 Knockout Cell Lines

Gene: ZDHHC9

Official Full Name: zDHHC palmitoyltransferase 9provided by HGNC

Gene Summary: This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04928 ZDHHC9 Knockout cell line (HeLa) Human ZDHHC9 1:3~1:6 Negative Online Inquiry
KO04929 ZDHHC9 Knockout cell line (HCT 116) Human ZDHHC9 1:2~1:4 Negative Online Inquiry
KO04930 ZDHHC9 Knockout cell line (HEK293) Human ZDHHC9 1:3~1:6 Negative Online Inquiry
KO04931 ZDHHC9 Knockout cell line (A549) Human ZDHHC9 1:3~1:4 Negative Online Inquiry

Background

ZDHHC9 Gene Knockout Cell Lines are specialized cellular models engineered to lack the ZDHHC9 gene, which encodes for a member of the DHHC zinc finger protein family involved in the palmitoylation of various substrates. This process is crucial for regulating protein localization, stability, and function within the cell. By utilizing CRISPR-Cas9 or similar gene-editing technologies, these knockout cell lines allow researchers to investigate the physiological and pathological roles of ZDHHC9 with greater precision.

The unique mechanism of action involves the disruption of ZDHHC9, leading to altered protein palmitoylation patterns which can significantly impact signal transduction pathways and cellular interactions. This disruption provides a valuable tool for scientists aiming to elucidate ZDHHC9's role in cellular processes such as neurodevelopment, synaptic function, and potentially its implication in diseases like autism and neurodegeneration.

In clinical and research settings, these cell lines hold significant scientific importance as they facilitate the study of gene function, the development of therapies, and the identification of novel drug targets. By employing ZDHHC9 knockout cell lines, researchers can create more accurate models that reflect the in vivo conditions pertinent to their studies, thereby enhancing the reliability of their experimental results.

One of the distinguishing advantages of our ZDHHC9 Gene Knockout Cell Lines is the high specificity and efficiency of gene knockout achieved through our proprietary optimization protocols, reducing off-target effects commonly seen with other gene-editing methods. Moreover, our cell lines come with thorough characterization, ensuring researchers have access to validated products that meet rigorous scientific standards.

Choosing ZDHHC9 Gene Knockout Cell Lines from our company not only ensures you advance your research with cutting-edge tools but also aligns you with a trusted source backed by years of expertise in genetic engineering and cellular biology. Our commitment to quality and innovation empowers researchers and clinicians alike to push the boundaries of understanding in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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