Gene: YWHAE
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonprovided by HGNC
Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10112 | YWHAE Knockout cell line (HeLa) | Human | YWHAE | 1:3~1:6 | Negative | Online Inquiry |
KO10113 | YWHAE Knockout cell line (HCT 116) | Human | YWHAE | 1:2~1:4 | Negative | Online Inquiry |
KO10114 | YWHAE Knockout cell line (HEK293) | Human | YWHAE | 1:3~1:6 | Negative | Online Inquiry |
KO10115 | YWHAE Knockout cell line (A549) | Human | YWHAE | 1:3~1:4 | Negative | Online Inquiry |
YWHAE Gene Knockout Cell Lines are specialized cell lines genetically modified to disrupt the expression of the YWHAE gene, which encodes a critical scaffold protein involved in various cellular signaling pathways. The knockout of this gene allows researchers to explore the functional role of YWHAE in cellular processes such as proliferation, apoptosis, and cell signaling dynamics. By utilizing CRISPR-Cas9 technology or similar gene-editing techniques, these cell lines effectively eliminate YWHAE expression, enabling precise studies of its implications in different biological contexts.
The primary function of YWHAE is to serve as an adapter in signaling cascades, particularly those involving growth factors and stress responses. Its knockout facilitates investigations into the pathways modulated by YWHAE, shedding light on mechanisms underlying diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. This product stands out in both research and clinical applications, offering investigators a robust tool for elucidating the molecular underpinnings of these conditions and potentially identifying novel therapeutic targets.
One of the significant advantages of YWHAE Gene Knockout Cell Lines is their specificity and relevance; unlike broad-spectrum inhibitors, these knockout lines provide a clean model for studying the precise effects of YWHAE absence. Furthermore, the reproducibility of CRISPR-generated knockout lines ensures that researchers can obtain consistent results across experiments, enhancing the reliability of their findings. Compared to alternative gene-editing strategies, such as RNA interference, which may not completely abolish protein function, these knockout cell lines provide a definitive analysis of YWHAE’s role.
Researchers, clinicians, and biotech companies seeking to deepen their understanding of cellular signaling pathways will find immense value in YWHAE Gene Knockout Cell Lines. Their precision and reliability not only expedite groundbreaking discoveries but also contribute to the advancement of therapeutic strategies targeting YWHAE-related pathways.
Our company prides itself on its cutting-edge expertise in genetic engineering and cell line development, ensuring that our products meet the highest standards of quality and scientific rigor. We are dedicated to supporting your research initiatives with innovative solutions tailored to enhance your scientific inquiries and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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