Gene: WWTR1
Official Full Name: WW domain containing transcription regulator 1provided by HGNC
Gene Summary: Enables transcription coactivator activity. Involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation. Located in cytosol and nuclear body. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09432 | WWTR1 Knockout cell line (HeLa) | Human | WWTR1 | 1:3~1:6 | Negative | Online Inquiry |
KO09433 | WWTR1 Knockout cell line (HCT 116) | Human | WWTR1 | 1:2~1:4 | Negative | Online Inquiry |
KO09434 | WWTR1 Knockout cell line (HEK293) | Human | WWTR1 | 1:3~1:6 | Negative | Online Inquiry |
WWTR1 Gene Knockout Cell Lines represent a groundbreaking tool in molecular biology designed to facilitate the study of the WWTR1 gene, known for its crucial role in various cellular processes, including cell proliferation, survival, and differentiation. These specially engineered cell lines have been created through precise gene-editing techniques, allowing researchers to completely remove functional WWTR1 protein expression, thus providing a robust platform to investigate the gene's contribution to specific biological phenomena.
The primary function of these knockout cell lines lies in their ability to mimic the loss-of-function scenario in studies assessing WWTR1-related pathways. By observing the resultant phenotypic changes and cellular behaviors, researchers can dissect the molecular underpinnings and functional consequences of WWTR1 deficiency. The mechanism involves CRISPR/Cas9 technology, which ensures specific and efficient targeting of the WWTR1 locus, leading to a clean knockout without off-target effects, thus preserving the integrity of downstream analyses.
Scientifically, WWTR1 has been implicated in various pathologies, including cancer and cardiovascular diseases. These cell lines serve as invaluable tools in both research and clinical settings, allowing for the exploration of therapeutic targets and understanding the role of WWTR1 in disease progression. Their use can yield insights into tumor biology, potentially paving the way for novel treatment strategies based on genetic modulation.
One of the specific advantages of our WWTR1 Gene Knockout Cell Lines is their reliability and reproducibility in experimental setups, as they are validated for consistent performance across multiple laboratories. Unlike other genetic manipulation approaches that may yield variable results, our knockout models provide a standardized platform that can be readily utilized for high-throughput screening and drug discovery efforts.
For researchers and clinicians alike, these cell lines are invaluable for elucidating the functional consequences of WWTR1 deficiency, which could lead to breakthroughs in our understanding of its role in disease mechanisms. The capacity to manipulate these specific cellular pathways equips scientists with the ability to test hypotheses accurately, ultimately contributing to advancements in therapeutic development.
With our extensive expertise in gene editing technologies and cellular biology, we are dedicated to providing high-quality biological products that accelerate research progress. Our WWTR1 Gene Knockout Cell Lines exemplify our commitment to innovation and excellence in the life sciences领域.
Please note that all services are for research use only. Not intended for any clinical use.
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