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WIPI2 Knockout Cell Lines

Gene: WIPI2

Official Full Name: WD repeat domain, phosphoinositide interacting 2provided by HGNC

Gene Summary: WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28326 WIPI2 Knockout cell line (HeLa) Human WIPI2 1:3~1:6 Negative Online Inquiry
KO28327 WIPI2 Knockout cell line (HCT 116) Human WIPI2 1:2~1:4 Negative Online Inquiry
KO28328 WIPI2 Knockout cell line (HEK293) Human WIPI2 1:3~1:6 Negative Online Inquiry
KO28329 WIPI2 Knockout cell line (A549) Human WIPI2 1:3~1:4 Negative Online Inquiry

Background

WIPI2 Gene Knockout Cell Lines are specialized cell models designed for the detailed study of the WIPI2 gene, which plays a critical role in the cellular processes of autophagy and lipid metabolism. These knockout models have been genetically engineered to silence the expression of the WIPI2 gene, thereby providing a unique platform to investigate the biological implications of its absence in cellular functions and disease states.

The primary mechanism of action involves the disruption of autophagosome formation, which WIPI2 significantly influences. By studying these knockout cell lines, researchers can elucidate the pathways that regulate autophagy and how the loss of WIPI2 affects the degradation of cytoplasmic components, the response to nutrient deprivation, and the overall cellular homeostasis. This can uncover the involvement of WIPI2 in various diseases, including neurodegenerative disorders and cancer, affirming its importance in both cellular biology and potential therapeutic contexts.

The scientific relevance of WIPI2 Gene Knockout Cell Lines is profound, as they provide a model that bridges fundamental research and clinical translational applications. These models enable researchers to explore novel treatment strategies, understand disease mechanisms, and contribute to the development of targeted therapies. Additionally, compared to traditional models, WIPI2 knockout lines offer higher specificity in studying the biological impacts of autophagic regulation, giving researchers the precision needed in their investigations.

With the increasing focus on autophagy in the scientific community, these knockout cell lines present a compelling advantage for researchers seeking reliable, reproducible results. Their use can accelerate the pace of discovery and innovation in the field. Furthermore, these models are accompanied by our comprehensive support and protocol optimization, providing users with a seamless research experience.

As a leader in the field of genetic engineering and cell line development, our company's expertise ensures that WIPI2 Gene Knockout Cell Lines are thoroughly validated and characterized, making them a valuable asset for laboratories focused on exploring the intricacies of autophagy and related disorders.

Please note that all services are for research use only. Not intended for any clinical use.

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