Gene: WFDC2
Official Full Name: WAP four-disulfide core domain 2provided by HGNC
Gene Summary: This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31899 | WFDC2 Knockout cell line (HEK293) | Human | WFDC2 | 1:3~1:6 | Negative | Online Inquiry |
WFDC2 Gene Knockout Cell Lines are specially engineered cellular models that have undergone precise genetic modification to disrupt the expression of the WFDC2 gene. This gene is implicated in various biological processes, including cell adhesion, immune response, and tissue remodeling. By creating knockout cell lines, researchers gain a pivotal tool for studying the functional consequences of WFDC2 deficiency, thereby enabling insights into its regulatory networks and associated pathological conditions.
The primary mechanism of action revolves around the targeted disruption of the WFDC2 gene through CRISPR/Cas9 or similar gene-editing technologies. This results in the absence of the gene product, allowing scientists to observe changes in cellular behavior, such as altered proliferation rates, differences in signaling pathways, or shifts in extracellular matrix composition. Such functional assays are crucial for understanding the role of WFDC2 in oncogenesis, inflammatory responses, and cellular differentiation.
The scientific importance of WFDC2 Gene Knockout Cell Lines extends to their broad applicability in both research and clinical settings. These cell lines can be utilized for drug discovery, biomarker validation, and the elucidation of disease mechanisms related to immune disorders or cancer biology. Their use not only aids in deciphering the complex interplay of genes but also enhances the translational potential of basic research findings into therapeutic advancements.
One significant advantage of these knockout models is their specificity; unlike traditional pharmacological inhibitors, which may affect multiple pathways, WFDC2 knockout cell lines provide precise insights linked directly to the absence of the gene. Moreover, they facilitate the development of tailored therapeutic strategies by allowing extensive screening of cellular responses to various stimuli.
For researchers and clinicians seeking to delve deep into gene function and disease pathology, WFDC2 Gene Knockout Cell Lines represent an invaluable resource. They are essential in uncovering mechanisms that could lead to novel therapeutic interventions and improved treatment modalities. Our company prides itself on delivering high-quality, rigorously validated biological products, ensuring that our clients have access to reliable models that support groundbreaking discoveries in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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