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VPS37D Knockout Cell Lines

Gene: VPS37D

Official Full Name: VPS37D subunit of ESCRT-Iprovided by HGNC

Gene Summary: Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in extracellular exosome. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12645 VPS37D Knockout cell line (HCT 116) Human VPS37D 1:2~1:4 Negative Online Inquiry
KO12646 VPS37D Knockout cell line (HEK293) Human VPS37D 1:3~1:6 Negative Online Inquiry
KO12647 VPS37D Knockout cell line (A549) Human VPS37D 1:3~1:4 Negative Online Inquiry

Background

VPS37D Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of VPS37D gene function by enabling researchers to observe the effects of complete gene disruption. VPS37D is a crucial component of the endosomal complex required for transport (ESCRT) machinery, which is essential for various cellular processes, including receptor downregulation, membrane scission, and MVB (multivesicular body) formation. The knockout of this gene allows for in-depth analysis of its role in cellular homeostasis, signal transduction, and potential contributions to disease.

The primary function of VPS37D Gene Knockout Cell Lines is to provide a controlled platform for investigating the consequences of VPS37D gene loss on cellular dynamics. Researchers can utilize these cell lines to elucidate pathways affected by VPS37D, explore its role in cellular processes such as exosome release, and analyze possible implications in cancer and neurodegenerative diseases. By understanding the mechanistic pathways that involve VPS37D, scientists can advance knowledge toward novel therapeutic strategies.

The scientific importance of VPS37D Gene Knockout Cell Lines extends to various applications in both basic and translational research. They serve as valuable tools in pharmacological studies, gene therapy research, and the development of targeted treatments. Furthermore, these knockout cell lines can be integrated into high-throughput screening assays for drug discovery, making them critical for identifying lead compounds that may mitigate disease-related deficiencies associated with VPS37D dysfunction.

Compared to alternative products, such as transient knockdown models, VPS37D Gene Knockout Cell Lines offer several distinct advantages, including stable gene disruption, reduced variability in experimental outcomes, and a more reproducible and long-term assessment of biological processes. In addition, their availability in multiple cellular contexts (e.g., human and mouse cell lines) provides researchers the flexibility to tailor experiments to suit specific needs.

For researchers and clinicians, the value of VPS37D Gene Knockout Cell Lines lies in their ability to yield reliable data that drive scientific discovery in molecular biology and therapeutic interventions. By employing these specialized tools, users can accelerate their research goals and expand their understanding of VPS37D-related pathways.

With decades of expertise in developing innovative genetic models, our company is committed to providing high-quality biological products that empower scientists to explore the complexities of life at the molecular level. We ensure our products meet rigorous standards, facilitating groundbreaking research in a constantly evolving scientific landscape.

Please note that all services are for research use only. Not intended for any clinical use.

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