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VASH1 Knockout Cell Lines

Gene: VASH1

Official Full Name: vasohibin 1provided by HGNC

Gene Summary: Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell proliferation; negative regulation of lymphangiogenesis; and regulation of cellular senescence. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30271 VASH1 Knockout cell line (HeLa) Human VASH1 1:3~1:6 Negative Online Inquiry
KO30272 VASH1 Knockout cell line (HCT 116) Human VASH1 1:2~1:4 Negative Online Inquiry
KO30273 VASH1 Knockout cell line (HEK293) Human VASH1 1:3~1:6 Negative Online Inquiry
KO30274 VASH1 Knockout cell line (A549) Human VASH1 1:3~1:4 Negative Online Inquiry

Background

VASH1 Gene Knockout Cell Lines represent a significant advancement in the field of molecular biology and genetics, specifically designed to facilitate the study of VASH1 (Vasohibin-1), a gene implicated in angiogenesis and vascular function. These engineered cell lines have been meticulously created by employing CRISPR-Cas9 technology, leading to the precise disruption of the VASH1 gene. This gene knockout enables researchers to explore the role of VASH1 in cellular processes, including cell proliferation, apoptosis, and wound healing, providing insights into its functional mechanisms.

The primary function of these cell lines is to serve as in vitro models that mimic specific physiological conditions where VASH1 activity is either absent or diminished. By studying these cell lines, researchers can elucidate the signaling pathways and molecular interactions influenced by VASH1, which has implications in conditions such as cancer, cardiovascular diseases, and inflammation. The knockout model allows for detailed examination of the gene's impact on angiogenic factors and other related pathways, fostering a deeper understanding of how VASH1 modulation could affect therapeutic interventions.

In research and clinical settings, the VASH1 Gene Knockout Cell Lines offer numerous advantages over traditional methods. The precision of CRISPR technology reduces off-target effects commonly associated with earlier gene-editing techniques, thereby ensuring more reliable data. Additionally, these cell lines can be rapidly generated and customized to match various experimental requirements, making them accessible and versatile for a range of applications, from drug discovery to toxicology assessments.

For researchers and clinicians, the value of these cell lines lies in their ability to provide an authentic representation of pathophysiological conditions. The ability to study the absence of VASH1 opens avenues for novel discoveries and therapeutic strategies aimed at modulating angiogenesis and improving patient outcomes in vascular-related diseases.

Our company specializes in providing high-quality, genetically modified cell lines that enable cutting-edge research applications. With expert insight and a commitment to scientific excellence, we strive to support the research community in unlocking the mysteries of gene function and its therapeutic potential.

Please note that all services are for research use only. Not intended for any clinical use.

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