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VAMP1 Knockout Cell Lines

Gene: VAMP1

Official Full Name: vesicle associated membrane protein 1provided by HGNC

Gene Summary: Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06159 VAMP1 Knockout cell line (HeLa) Human VAMP1 1:3~1:6 Negative Online Inquiry
KO06160 VAMP1 Knockout cell line (HCT 116) Human VAMP1 1:2~1:4 Negative Online Inquiry
KO06161 VAMP1 Knockout cell line (HEK293) Human VAMP1 1:3~1:6 Negative Online Inquiry
KO06162 VAMP1 Knockout cell line (A549) Human VAMP1 1:3~1:4 Negative Online Inquiry

Background

VAMP1 Gene Knockout Cell Lines are specifically engineered cell lines that have undergone targeted deletion of the vesicle-associated membrane protein 1 (VAMP1) gene, which plays a crucial role in neurotransmitter release and synaptic vesicle trafficking. This unique product allows researchers to investigate the biological implications of VAMP1 absence in cellular processes, making it an invaluable tool in neurobiology and cellular signaling studies.

The primary function of these cell lines revolves around their ability to facilitate the observation of cellular behavior without the influence of the VAMP1 gene. By employing CRISPR/Cas9 gene editing techniques, VAMP1 Gene Knockout Cell Lines provide a controlled environment to analyze the mechanistic pathways involved in synaptic function, contribute to the understanding of neurodegenerative diseases, and elucidate the role of VAMP1 in various cellular processes such as membrane fusion and intracellular transport.

From a scientific perspective, these cell lines have significant applications in both research and clinical settings. They can be utilized in studies aimed at understanding the molecular underpinnings of conditions such as epilepsy, schizophrenia, and other neuropathologies, where synaptic dysfunction is often observed. Furthermore, the insights gained from using VAMP1 knockout models can lead to the development of innovative therapeutic strategies targeting synaptic delivery mechanisms.

What sets VAMP1 Gene Knockout Cell Lines apart from alternative models is their high fidelity in mimicking physiological conditions, combined with robust reproducibility. Researchers benefit from the time-saving aspect of having ready-to-use, genetically modified cell lines that eliminate the need for lengthy gene editing processes that could introduce undesired variables.

For researchers and clinicians alike, the value of VAMP1 Gene Knockout Cell Lines lies in their potential to facilitate cutting-edge discoveries and therapeutic advancements. The ability to study gene function in a controlled environment accelerates the path from bench to bedside, ultimately translating basic research into clinical innovation.

Our company, with its longstanding expertise in genetic engineering and molecular biology products, is committed to providing high-quality biological tools that empower scientists and healthcare professionals in their quest for knowledge and therapeutic breakthroughs. Our dedication to precision and reliability makes us a trusted partner in advancing research and improving outcomes in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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