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USP48 Knockout Cell Lines

Gene: USP48

Official Full Name: ubiquitin specific peptidase 48provided by HGNC

Gene Summary: This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03410 USP48 Knockout cell line (HeLa) Human USP48 1:3~1:6 Negative Online Inquiry
KO03411 USP48 Knockout cell line (HCT 116) Human USP48 1:2~1:4 Negative Online Inquiry
KO03412 USP48 Knockout cell line (HEK293) Human USP48 1:3~1:6 Negative Online Inquiry
KO03413 USP48 Knockout cell line (A549) Human USP48 1:3~1:4 Negative Online Inquiry

Background

USP48 Gene Knockout Cell Lines are specialized biological products engineered to lack the expression of the USP48 gene, a crucial component in various cellular processes, including protein degradation, cell cycle regulation, and stress response. These cell lines serve as invaluable tools for investigating the functional implications of USP48 in diverse biological contexts.

These cell lines utilize sophisticated gene-editing technologies, such as CRISPR/Cas9, to precisely eliminate USP48 expression, allowing researchers to study its role in cellular mechanisms and disease processes. By manipulating USP48 levels, researchers can gain insights into pathways associated with cancer, neurodegeneration, and metabolic disorders, as USP48 has been linked to the regulation of proteins involved in these conditions.

The scientific importance of USP48 Gene Knockout Cell Lines extends into both research and clinical applications. They facilitate the identification of new therapeutic targets by enabling the analysis of USP48's role in gene regulation and its interactions with other cellular factors. Furthermore, these cell lines can assist in drug screening processes, helping to elucidate how USP48 modulation might impact cellular sensitivity to various pharmacological agents.

Compared to traditional methods of gene knockdown, such as siRNA or shRNA treatments, USP48 Gene Knockout Cell Lines provide a stable and permanent alteration in gene expression, resulting in more reproducible and robust experimental outcomes. This permanence is critical for long-term studies and enhances experimental accuracy.

For researchers and clinicians, the ability to study the precise effects of USP48 loss in a controlled environment opens new avenues for exploring therapeutic interventions. These unique cell lines are designed to expedite scientific discovery, reduce variability in experimental data, and ultimately contribute to the development of targeted therapies in precision medicine.

Our company prides itself on pioneering advancements in biological products, employing cutting-edge methodologies to produce high-quality cell lines that meet the rigorous demands of contemporary research. Through our expertise, we ensure that researchers have access to the best tools available, empowering innovation and discovery in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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