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USP38 Knockout Cell Lines

Gene: USP38

Official Full Name: ubiquitin specific peptidase 38provided by HGNC

Gene Summary: Enables cysteine-type deubiquitinase activity and protein sequestering activity. Involved in negative regulation of innate immune response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K33-linked deubiquitination. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24757 USP38 Knockout cell line (HeLa) Human USP38 1:3~1:6 Negative Online Inquiry
KO24758 USP38 Knockout cell line (HCT 116) Human USP38 1:2~1:4 Negative Online Inquiry
KO24759 USP38 Knockout cell line (HEK293) Human USP38 1:3~1:6 Negative Online Inquiry
KO24760 USP38 Knockout cell line (A549) Human USP38 1:3~1:4 Negative Online Inquiry

Background

USP38 Gene Knockout Cell Lines are specifically engineered cellular models that have had the USP38 gene functionally disrupted through the use of CRISPR-Cas9 technology. This precise knockout allows researchers to explore the role of USP38 in various biological processes, including gene regulation, cellular proliferation, and response to stress signals, providing essential insights into its contributions to cellular homeostasis and disease mechanisms.

The primary function of these cell lines revolves around the study of ubiquitin-specific proteases, particularly USP38, which can modulate protein stability and cellular pathways by cleaving ubiquitin moieties from target proteins. By utilizing these knockout cell lines, researchers can elucidate how the absence of USP38 affects signaling cascades and biochemical networks, thereby improving our understanding of its implications in diseases such as cancer and neurological disorders.

In the context of research and clinical applications, USP38 Gene Knockout Cell Lines serve as invaluable tools for drug discovery and development, allowing scientists to identify potential therapeutic targets and validate the efficacy of pharmacological agents. Their use can also accelerate biomarker discovery and contribute to the development of personalized medicine approaches, enhancing patient outcomes.

Compared to alternative models, these knockout cell lines offer a greater level of specificity and control, minimizing background effects and enhancing data reliability. Their generation through the CRISPR-Cas9 method ensures high efficiency and reproducibility, making them a superior option for researchers seeking to conduct high-impact studies.

For researchers and clinicians, the ability to manipulate the USP38 pathway in these versatile cell lines opens new avenues for innovation in basic and applied sciences. The availability of USP38 Gene Knockout Cell Lines from our company, which specializes in high-quality biological products, underscores our commitment to empowering the scientific community with advanced tools necessary for cutting-edge research. With our expertise and focus on precision, we provide products that not only enhance experimental outcomes but also advance the frontiers of biological knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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