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USP30 Knockout Cell Lines

Gene: USP30

Official Full Name: ubiquitin specific peptidase 30provided by HGNC

Gene Summary: USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24663 USP30 Knockout cell line (HeLa) Human USP30 1:3~1:6 Negative Online Inquiry
KO24664 USP30 Knockout cell line (HCT 116) Human USP30 1:2~1:4 Negative Online Inquiry
KO24665 USP30 Knockout cell line (HEK293) Human USP30 1:3~1:6 Negative Online Inquiry
KO24666 USP30 Knockout cell line (A549) Human USP30 1:3~1:4 Negative Online Inquiry

Background

USP30 Gene Knockout Cell Lines are an innovative biological research tool derived from advanced gene editing techniques. These cell lines are specifically designed to lack the USP30 gene, a critical regulator of mitochondrial dynamics and cellular signaling pathways. By utilizing CRISPR-Cas9 technology, our USP30 Gene Knockout Cell Lines ensure precise deletion of the gene, facilitating in-depth functional studies on mitochondrial function, metabolic pathways, and their implications in various diseases.

The primary function of these knockout cell lines is to enable researchers to explore the role of USP30 in cellular processes such as regulation of apoptosis, mitochondrial morphology, and reactive oxygen species (ROS) generation. The absence of USP30 allows for comprehensive analysis of its effects on cellular respiration and viability, providing a clearer understanding of mitochondrial pathophysiology linked to neurodegenerative diseases and cancer. These cell lines serve as invaluable models for pharmacological assessments and are essential in the drug discovery process targeting mitochondrial dysfunction.

The scientific significance of USP30 Gene Knockout Cell Lines extends to their applications in both basic and translational research. They are particularly useful for investigating the interplay between mitochondrial health and cellular aging, and for assessing new therapeutic strategies aimed at mitochondrial diseases. Compared to traditional cell lines, our USP30 knockouts represent a direct approach to studying gene functionality and gene-environment interactions, enhancing the relevance of experimental findings.

One of the standout advantages of our USP30 Gene Knockout Cell Lines is the precision of the gene-editing method used during their development. This results in greater reproducibility and reliability in experimental outcomes than alternative models that utilize pharmacological inhibitors or inferior genetic editing techniques. Furthermore, our cell lines are validated for consistent growth and performance, ensuring that researchers can conduct high-quality experiments with confidence.

Researchers and clinicians looking to unlock new avenues in mitochondrial research will find these cell lines invaluable to their efforts, complementing their experimental designs with reliable, cutting-edge tools. Our commitment to excellence in biotechnology and a deep understanding of genetic technology positions us as leaders in producing high-quality biological products that catalyze scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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